Evidence map›Paper›PMID 36607529›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2023

Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads.

Alexander C Perino, Paul J Wang, Michael Lloyd, Francesco Zanon, Katsuhito Fujiu, Faizel Osman, Sem Briongos-Figuero, Toshiaki Sato, Tolga Aksu, Marek Jastrzebski and 82 more

Abstract read
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Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Clinical indications for conduction system pacing in routine practice: 2025 survey from the Home Monitoring Expert Alliance.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  2. Article
  3. Safety and performance of the Medtronic 3830 lead in His-bundle and Left bundle branch area pacing: A single-center experience.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
  4. Mid-term clinical outcomes of left bundle branch area pacing compared to accurate right ventricular septal pacing.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

92 authors.

Alexander C PerinoCenter for Academic Medicine, Department of Medicine/Division of Cardiovascular Medicine, Stanford University School of Medicine, 453 Quarry Road, Palo Alto, CA, 94304, USA. aperino@stanford.edu.ORCID http://orcid.org/0000-0001-5482-8055
Paul J WangCenter for Academic Medicine, Department of Medicine/Division of Cardiovascular Medicine, Stanford University School of Medicine, 453 Quarry Road, Palo Alto, CA, 94304, USA.
Michael LloydEmory University School of Medicine, Atlanta, USA.
Francesco ZanonSanta Maria Della Misericordia General Hospital, Perugia, Italy.
Katsuhito FujiuThe University of Tokyo, Tokyo, Japan.
Faizel OsmanUniversity Hospital Coventry, Conventry, UK.
Sem Briongos-FigueroHospital Universitario Infanta Leonor, Madrid, Spain.
Toshiaki SatoKyorin University School of Medicine, Mitaka, Japan.
Tolga AksuYeditepe University Hospital, Istanbul, Turkey.
Marek JastrzebskiSchool of Mdeicine, Jagiellonian University, Krakow, Poland.
Skevos SiderisHippokration General Hospital, Athens, Greece.
Praveen RaoBaylor University Medical Center, Dallas, USA.
Krzysztof BoczarThe John Paul II Hospital, Krakow, Poland.
Xu Yuan-NingWest China Hospital, Sichuan University, Chengdu, China.
Michael WuLifespan Cardiovascular Institute, Brown University, Providence, USA.
Narayanan NamboodiriSree Chitra Institute for Medical Sciences and Technology, Thiruvananthapuram, India.
Rodrigue GarciaUniversity Hospital of Poitiers, Poitiers, France.
Vikas KatariaHoly Family Hospital, New Delhi, India.
Jan De PooterUniversity Hospital Ghent, Ghent, Belgium.
Oliver PrzibilleCardioangiologic Centre Bethanien, Frankfurt, Germany.
Anil K GehiUniversity of North Carolina School of Medicine, Chapel Hill, USA.
Oscar CanoHospital Universitari I Politècnic La Fe, Valencia, Spain.
Grigorios KatsourasEnte Ecclesiastico Ospedale Miulli, Acquaviva Delle Fonti BA, Italy.
Binni CaiXiamen Cardiovascular Hospital, Xiamen, China.
Klaus AstheimerUniversity Hospital Freiburg, Freiburg, Germany.
Tanyanan TanawuttiwatKrannert Institute of Cardiology, Indiana University, Avon, IN, USA.
Tomas DatinoHospital General Universitario Gregorio Marañon, Madrid, Spain.
Jacques RizkallahUniversity of Calgary, Calgary, Canada.
Mohammad AlastiMonash Health, Melbourne, Australia.
Gregory FeldUniversity of California San Diego Health System, San Diego, USA.
Maria Teresa Barrio-LopezHospital HM Monteprincipe, Madrid, Spain.
Mark GilmorePrincess of Wales Hospital, Bridgend, UK.
Sergio ContiARNAS Civico Hospital, Palermo, Italy.
Satoshi YanagisawaNagoya University Graduate School of Medicine, Nagoya, Japan.
Julia H IndikUniversity of Arizona College of Medicine, Tucson, USA.
Jiangang ZouFirst Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial Hospital, Nanjing, China.
Sandeep A SahaOregon Heart Center, Salem, USA.
Daniel Rodriguez-MunozUniversity Hospital, October 12, Madrid, Spain.
Kuan-Cheng ChangSchool of Medicine, China Medical University, Taichung, Taiwan.
Dmitry S LebedevNational Medical Research Center. VA Almazov, Saint Petersburg, Russia.
Miguel A LealSchool of Medicine and Public Health, University of Wisconsin, Madison, USA.
Andreas HaeberlinBern University Hospital, Bern, Switzerland.
Alexander R J Dal FornoSOS Cardio-Cardiology Hospital Center, Florianópolis, Brazil.
Michael OrlovSteward St.Elizabeth's Medical Center, Boston, USA.
Manuel FrutosHospital Universitario Virgen del Rocío, Seville, Spain.
Pilar Cabanas-GrandioHospital Alvaro Cunqueiro, Vigo, Spain.
Jonathan LyneBeacon Hospital, Dublin, Ireland.
Francisco LeyvaAston University, Birmingham, UK.
Jose Maria TolosanaHospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
Pierre OllitraultCaen University Hospital, Caen, France.
Pasquale VergaraSan Raffaele Scientific Institute, Segrate, Italy.
Cristina BallaAzienda Ospedaliero Universitaria Di Ferrara, Cona, Italy.
Subodh R DevabhaktuniUniversity of Arkansas Medical Sciences, Little Rock, USA.
Giovanni ForleoOspedale Luigi Sacco, Milan, Italy.
Konstantinos P LetsasOnassis Cardiac Surgery Center, Kallithea, Greece.
Atul VermaSouthlake Regional Health Centre, Newmarket, Canada.
Jeffrey P MoakChildren's National Hospital, Washington, D.C, USA.
Abhijeet B ShelkeKrishna Institute of Medical Sciences, Karad, India.
Karol CurilaCardiocenter, 3Rd Faculty of Medicine, Charles University, Prague, Czechia.
Edmond M CroninLewis Katz School of Medicine at, Temple University, Philadelphia, USA.
Piotr FutymaMedical College, University of Rzeszów, Rzeszów, Poland.
Elaine Y WanColumbia University, New York, NY, USA.
Pietro Enea LazzeriniUniversity of Siena, Siena, Italy.
Felipe BisbalUniversity Hospital Germans Trias I Pujol, Barcelona, Spain.
Michela CasellaMarche Polytechnic University, Ancona, Italy.
Gioia TurittoNew York-Presbyterian Brooklyn Methodist Hospital, New York, NY, USA.
Lawrence RosenthalUMass Memorial Health Cancer Center, Worcester, USA.
T Jared BunchUniversity of Utah School of Medicine, Salt Lake City, USA.
Artur BaszkoPoznań University of Medical Sciences, Poznań, Poland.
Nicolas ClementyUniversity of Tours, Tours, France.
Yong-Mei ChaMayo Clinic, Rochester, USA.
Huang-Chung ChenKaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Vincent GalandUniversity Hospital of Rennes, Rennes, France.
Robert SchallerHospital of the University of Pennsylvania, Philadelphia, USA.
Julian W E JarmanRoyal Brompton Hospital, London, UK.
Masahide HaradaFujita Health University, Toyoake, Japan.
Yong WeiShanghai General Hospital, Shanghai, China.
Kengo KusanoNational Cerebral and Cardiovascular Center, Suita, Japan.
Constanze SchmidtUniversity Hospital Heidelberg, Heidelberg, Germany.
Marco Antonio Arguello HurtadoHospital Salud Integral, Managua, Nicaragua.
Niyada NaksukUniversity of Nebraska Medical Center, Omaha, USA.
Tadashi HoshiyamaKumamoto University Hospital, Kumamoto, Japan.
Krishna KancharlaUniversity of Pittsburgh, Pittsburgh, USA.
Yoji IidaKobari General Hospital, Noda, Japan.
Mashiro MizobuchiKyoto-Katsura Hospital, Kyoto, Japan.
Daniel P MorinOchsner Medical Center, New Orleans, USA.
Serkan CayAnkara City Hospital, Ankara, Turkey.
Gabriele PaglinoIRCCS San Raffaele Hospital, Segrate, Italy.
Tillman DahmeUniversitätsklinikum Ulm (Ulm University Medical Center), Ulm, Germany.
Sharad AgarwalRoyal Papworth Hospital NHS Trust, Cambridge, UK.
Pugazhendhi VijayaramanGeisinger Heart Institute, Danville, USA.
Parikshit S SharmaRush University Medical Center, Chicago, USA.

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
NCATS NIH HHS UL1 TR001085NCATS NIH HHS UL1 TR003142
6 · The paper itself

Abstract

backgroundAdoption and outcomes for conduction system pacing (CSP), which includes His bundle pacing (HBP) or left bundle branch area pacing (LBBAP), in real-world settings are incompletely understood. We sought to describe real-world adoption of CSP lead implantation and subsequent outcomes.

methodsWe performed an online cross-sectional survey on the implantation and outcomes associated with CSP, between November 15, 2020, and February 15, 2021. We described survey responses and reported HBP and LBBAP outcomes for bradycardia pacing and cardiac resynchronization CRT indications, separately.

resultsThe analysis cohort included 140 institutions, located on 5 continents, who contributed data to the worldwide survey on CSP. Of these, 127 institutions (90.7%) reported experience implanting CSP leads. CSP and overall device implantation volumes were reported by 84 institutions. In 2019, the median proportion of device implants with CSP, HBP, and/or LBBAP leads attempted were 4.4% (interquartile range [IQR], 1.9-12.5%; range, 0.4-100%), 3.3% (IQR, 1.3-7.1%; range, 0.2-87.0%), and 2.5% (IQR, 0.5-24.0%; range, 0.1-55.6%), respectively. For bradycardia pacing indications, HBP leads, as compared to LBBAP leads, had higher reported implant threshold (median [IQR]: 1.5 V [1.3-2.0 V] vs 0.8 V [0.6-1.0 V], p = 0.0008) and lower ventricular sensing (median [IQR]: 4.0 mV [3.0-5.0 mV] vs. 10.0 mV [7.0-12.0 mV], p < 0.0001).

conclusionIn conclusion, CSP lead implantation has been broadly adopted but has yet to become the default approach at most surveyed institutions. As the indications and data for CSP continue to evolve, strategies to educate and promote CSP lead implantation at institutions without CSP lead implantation experience would be necessary.

Indexed as

BradycardiaBundle of HisCardiac Conduction System DiseaseCardiac Pacing, ArtificialCross-Sectional StudiesElectrocardiographyHeart Conduction SystemHumansTreatment OutcomeConduction system pacingHis bundle pacingLeft bundle branch area pacing

Identifiers

PMID36607529
PMCPMC9817436

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.