Evidence map›Paper›PMID 36607491›Full record

ArticleClinical oral investigations2023

Bleaching effectiveness and cytotoxicity of new experimental formulation of niobium-based bleaching gel.

Camila de Sousa Caneschi, Francine Benetti, Luiz Carlos Alves de Oliveira, Jadson Cláudio Belchior, Raquel Conceição Ferreira, Allyson Nogueira Moreira, Luís Fernando Dos Santos Alves Morgan

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Camila de Sousa CaneschiDepartment of Restorative Dentistry, Federal University of Minas Gerais, Avenida Antônio Carlos, 6627 - Bairro Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Francine BenettiDepartment of Restorative Dentistry, Federal University of Minas Gerais, Avenida Antônio Carlos, 6627 - Bairro Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Luiz Carlos Alves de OliveiraDepartment of Chemistry, Federal University of Minas Gerais, Avenida Antônio Carlos, 6627 - Bairro Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Jadson Cláudio BelchiorDepartment of Chemistry, Federal University of Minas Gerais, Avenida Antônio Carlos, 6627 - Bairro Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Raquel Conceição FerreiraDepartment of Social and Preventive Dentistry, Federal University of Minas Gerais, Avenida Antônio Carlos, 6627 - Bairro Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Allyson Nogueira MoreiraDepartment of Restorative Dentistry, Federal University of Minas Gerais, Avenida Antônio Carlos, 6627 - Bairro Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil. allysonnogueiradangelo@gmail.com.
Luís Fernando Dos Santos Alves MorganDepartment of Restorative Dentistry, Federal University of Minas Gerais, Avenida Antônio Carlos, 6627 - Bairro Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe development of new bleaching agents with minimum concentration of hydrogen peroxide (HP), without adverse effects, and with bleaching effectiveness, has great clinical relevance. The aim of this study was to evaluate the bleaching efficacy and cytotoxicity of a new niobium-based bleaching gel, compared to already available HP-based gels. MATERIALS AND

methodsFor the bleaching efficacy analysis, 40 bovine incisors were randomly divided into 4 groups according to the established bleaching protocol: control, untreated; 35HP, 35% HP bleaching gel; 6HP, 6% HP bleaching gel; NbHP, niobium gel associated with 3% HP gel. The color variation was measured in a spectrophotometer and the values of ΔL, Δa, Δb, and ΔE obtained. For the cell viability assay by MTT, MC3T3 cells were exposed to bleaching gel extracts (1:500, 1:250, 1:125 dilutions; immediately and 24 h). Statistical tests were performed (P < 0.05).

resultsThe color alteration for all bleaching gels was significant compared to control (P < 0.05), but the NbHP gel showed a significant ΔE than other gels, with expressive color alteration at 14 days (P < 0.05). The 35HP showed high cytotoxicity regarding control and the most groups in all periods and extracts analyzed (P < 0.05), while the NbHP showed greater cell viability than control in the immediate period, dilution of the 1:500 and superior to 6HP in the most extracts at 24 h.

conclusionThe new experimental niobium-based gel has bleaching efficacy similar to that of gels with a high concentration of HP, and it has high cytocompatibility. CLINICAL RELEVANCE: The use of this new generation of niobium-based whitening gel associated with a low concentration of hydrogen peroxide represents the possibility of a tooth whitening with lower dentin sensitivity.

Indexed as

Tooth BleachingTooth Bleaching AgentsAnimalsCattleGelsHydrogen PeroxideNiobiumGelsHydrogen PeroxideNiobiumTooth Bleaching AgentsBleaching effectivenessBleaching gelCytotoxicityNiobium

Identifiers

PMID36607491

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.