Evidence map›Paper›PMID 36607469›Full record

ArticleThe international journal of cardiovascular imaging2023

Abnormal left ventricular subendocardial perfusion and diastolic function in women with obesity and heart failure and preserved ejection fraction.

Roshanak Markley, Marco Giuseppe Del Buono, Virginia Mihalick, Alexander Pandelidis, Cory Trankle, Jennifer H Jordan, Kevin Decamp, Chris Winston, Salvatore Carbone, Hayley Billingsley and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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  10. Society for Cardiovascular Magnetic Resonance 2024 Cases of SCMR case series.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Roshanak MarkleyVCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, PO Box 980036, 23219, Richmond, VA, USA. roshanak.markley@vcuhealth.org.ORCID http://orcid.org/0000-0001-9676-3333
Marco Giuseppe Del BuonoDepartment of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy.
Virginia MihalickVCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, PO Box 980036, 23219, Richmond, VA, USA.
Alexander PandelidisVCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, PO Box 980036, 23219, Richmond, VA, USA.
Cory TrankleVCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, PO Box 980036, 23219, Richmond, VA, USA.
Jennifer H JordanVCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, PO Box 980036, 23219, Richmond, VA, USA.
Kevin DecampDepartment of Radiology, Virginia Commonwealth University, Richmond, VA, USA.
Chris WinstonDepartment of Radiology, Virginia Commonwealth University, Richmond, VA, USA.
Salvatore CarboneVCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, PO Box 980036, 23219, Richmond, VA, USA.
Hayley BillingsleyVCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, PO Box 980036, 23219, Richmond, VA, USA.
Andrew BarronC. Kenneth and Diane Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA, USA.
Georgia ThomasVCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, PO Box 980036, 23219, Richmond, VA, USA.
Benjamin Van TassellDepartment of Pharmacotherapy and Outcome Sciences, Virginia Commonwealth University, Richmond, VA, USA.
W Gregory HundleyVCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, PO Box 980036, 23219, Richmond, VA, USA.
Peter KellmanNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Antonio AbbateVCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, PO Box 980036, 23219, Richmond, VA, USA.
Virginia Commonwealth University · USNational Institutes of Health · USUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose- Coronary microvascular dysfunction (CMD) is common in patients with heart failure with preserved ejection fraction (HFpEF) and obesity. Stress cardiovascular magnetic resonance (CMR) has been proposed as a non-invasive tool for detection of CMD. The aim of this study was to determine relationship between CMD and diastolic function in patients with HFpEF using a novel CMR technique.

methods- Patients with obesity and HFpEF without epicardial coronary artery disease (CAD) underwent Doppler echocardiography to measure diastolic function, followed by vasodilator stress CMR, using a single bolus, dual sequence, quantitative myocardial perfusion mapping to measure myocardial blood flow (MBF) at rest and at peak hyperemia. With this, myocardial perfusion reserve (MPR), global stress endocardial-to-epicardial (endo:epi) perfusion ratio, and total ischemic burden (IB, defined as myocardial segments with MBF < 1.94 mL/min/g) were calculated. Results are reported as median and interquartile range.

results- Nineteen subjects were enrolled (100% female, 42% Black). Median age was 64 [56-72] years. Global stress MBF was 2.43 ml/min/g [2.16-2.78] and global myocardial perfusion reserve (MPR) was 2.34 [2.07-2.88]. All had an abnormal subendocardial perfusion with an endo:epi of less than 1 (0.87 [0.81-0.90]). Regional myocardial hypoperfusion was detected in 14 (74%) patients with an IB of 6% [0-34.4]. Endo:epi ratio significantly correlated with IB (R=-0.510, p = 0.026) and measures of diastolic function (R = 0.531, p = 0.019 and R=-0.544, p = 0.014 for e' and E/e' respectively).

conclusion- Using a novel quantitative stress CMR myocardial perfusion mapping technique, women with obesity and HFpEF were found to have patterns of abnormal subendocardial perfusion which significantly correlated with measures of diastolic dysfunction.

Indexed as

Coronary Artery DiseaseHeart FailureMyocardial IschemiaCoronary CirculationFemaleHumansMiddle AgedObesityPerfusionPredictive Value of TestsStroke VolumeVentricular Function, LeftHeart failure with preserved ejection fractionMicrovascular dysfunctionQuantitative myocardial perfusion mapping

Identifiers

PMID36607469
PMCPMC9816541
OpenAlexW4313647750

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.