Evidence map›Paper›PMID 36606666›Full record

ReviewBMJ open2022

Towards definitions of critical illness and critical care using concept analysis.

Raphael Kazidule Kayambankadzanja, Carl Otto Schell, Martin Gerdin Wärnberg, Thomas Tamras, Hedi Mollazadegan, Mats Holmberg, Helle Molsted Alvesson, Tim Baker

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 73 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 4 pooled it
23.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06051526 completednot on this mapstarted 2023, after this paper: background citation

The African Critical Illness Outcomes Study

TypeobservationalSponsorUniversity of Cape TownRan2023 to 2024Enrolled20,159ConditionsCritical Illness, Mortality
NCT06999291 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of Ovarian Reserve in Critically Ill Patients Followed in the Intensive Care Unit

TypeobservationalSponsorHaseki Training and Research HospitalRan2025 to 2025Enrolled75ConditionsAnti-Mullerian Hormone DeficiencyArmsGlaskow coma scala, The Acute Physiology and Chronic Health Evaluation System- APACHE, Injury Severity Score- ISS)
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 4 syntheses or guidelines pooled it, 160 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Research priorities for intensive care: A stakeholder-informed priority-setting partnership.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026
    Article
  7. Article
  8. Article
  9. Observational
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Critical illness in prisons: a multi-methods analysis of reported healthcare safety incidents in England.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026
    Article
  17. Observational
  18. Article
  19. Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 4 countries.

Raphael Kazidule KayambankadzanjaPublic Health, Kamuzu University of Health Sciences, Blantyre, Malawi.ORCID 0000-0003-2242-8975
Carl Otto SchellGlobal Public Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-7904-1336
Martin Gerdin WärnbergGlobal Public Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6069-4794
Thomas TamrasInternal Medicine, Södertälje Hospital, Stockholm, Sweden.ORCID 0000-0003-3131-8524
Hedi MollazadeganAddiction Medicine, Sankt Goran Hospital, Stockholm, Sweden.
Mats HolmbergCentre for Clinical Research Sörmland, Uppsala University, Eskilstuna, Sweden.ORCID 0000-0003-1878-0992
Helle Molsted AlvessonGlobal Public Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6109-7203
Tim BakerGlobal Public Health, Karolinska Institutet, Stockholm, Sweden Tim.Baker@ki.se.ORCID 0000-0001-8727-7018
Uppsala University · SEKamuzu Central Hospital · MWKarolinska Institutet · SEKarolinska University Hospital · SEMuhimbili University of Health and Allied Sciences · TZSaint Göran Hospital · SESödertälje Sjukhus · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAs 'critical illness' and 'critical care' lack consensus definitions, this study aimed to explore how the concepts' are used, describe their defining attributes, and propose potential definitions. DESIGN AND

methodsWe used the Walker and Avant approach to concept analysis. The uses and definitions of the concepts were identified through a scoping review of the literature and an online survey of 114 global clinical experts. We used the Arksey and O'Malley framework for scoping reviews and searched in PubMed and Web of Science with a strategy including terms around critical illness/care and definitions/etymologies limited to publications in English between 1 January 2008 and 1 January 2020. The experts were selected through purposive sampling and snowballing, with 36.8% in Africa, 25.4% in Europe, 22.8% in North America, 10.5% in Asia, 2.6% in South America and 1.8% in Australia. They worked with anaesthesia or intensive care 59.1%, emergency care 15.8%, medicine 9.5%, paediatrics 5.5%, surgery 4.7%, obstetrics and gynaecology 1.6% and other specialties 3.9%. Through content analysis of the data, we extracted codes, categories and themes to determine the concepts' defining attributes and we proposed potential definitions. To assist understanding, we developed model, related and contrary cases concerning the concepts, we identified antecedents and consequences to the concepts, and defined empirical referents.

resultsNine and 13 articles were included in the scoping reviews of critical illness and critical care, respectively. A total of 48 codes, 14 categories and 4 themes were identified in the uses and definitions of critical illness and 60 codes, 13 categories and 5 themes for critical care. The defining attributes of critical illness were a high risk of imminent death; vital organ dysfunction; requirement for care to avoid death; and potential reversibility. The defining attributes of critical care were the identification, monitoring and treatment of critical illness; vital organ support; initial and sustained care; any care of critical illness; and specialised human and physical resources. The defining attributes led to our proposed definitions of critical illness as, 'a state of ill health with vital organ dysfunction, a high risk of imminent death if care is not provided and the potential for reversibility', and of critical care as, 'the identification, monitoring and treatment of patients with critical illness through the initial and sustained support of vital organ functions.'

conclusionThe concepts critical illness and critical care lack consensus definitions and have varied uses. Through concept analysis of uses and definitions in the literature and among experts, we have identified the defining attributes of the concepts and proposed definitions that could aid clinical practice, research and policy-making.

Indexed as

Emergency Medical ServicesGynecologyChildHumansMultiple Organ FailureNorth AmericaPolicy Makingaccident & emergency medicineadult intensive & critical carehealth services administration & management

Identifiers

PMID36606666
PMCPMC9445819
OpenAlexW4294636915

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.