ArticleACS infectious diseases2023
Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome
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In one paragraph
Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- A Multi-Scale Computational Framework for Anti-Persister Tuberculosis Drug Discovery.Chemical biology & drug design · 2026Review
- Multidrug-resistant tuberculosis: a comprehensive review of pathogenesis, drug resistance, current treatment and future prospects.Archives of microbiology · 2026Review
- Second-Generation Anti-Tubercular Squaramides Targeting Complex V of the Respiratory Chain ofJournal of medicinal chemistry · 2026Article
- Inhibitors of cytochromemBio · 2026Article
- Investigating the role of cytochromeRSC medicinal chemistry · 2026Article
- A Series of Pyrazolo-Quinazoline Amines Inhibits the CytochromeJournal of medicinal chemistry · 2026Article
- Remission spectroscopy resolves the mechanism of action of bedaquiline within living mycobacteria.Nature communications · 2025Article
- Carbon Monoxide and Prokaryotic Energy Metabolism.International journal of molecular sciences · 2025Review
- Steroid Drugs Inhibit Bacterial Respiratory Oxidases and Are Lethal Toward Methicillin-Resistant Staphylococcus aureus.The Journal of infectious diseases · 2024Article
- Therapeutic developments for tuberculosis and nontuberculous mycobacterial lung disease.Nature reviews. Drug discovery · 2024Review
- CytochromeRSC medicinal chemistry · 2024Review
- A Chemoproteomic Approach to Elucidate the Mechanism of Action of 6-Azasteroids with Unique Activity in Mycobacteria.ACS infectious diseases · 2023Article
- Telacebec Interferes with Virulence Lipid Biosynthesis Protein Expression and Sensitizes to Other Antibiotics.Microorganisms · 2023Article
- Breakthroughs in the development of antibiotics, antifungals and antiparasitics targeting the pathogens' respiratory chain.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 4 institutions in 2 countries.
Laura N JeffreysCentre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K.ORCID 0000-0002-0607-6116
Alison ArdreyCentre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K.
Taghreed A HafizCentre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K.
Lauri-Anne DyerCentre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K.
Ashley J WarmanCentre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K.
Nada MosallamDepartment of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K.
Gemma L NixonDepartment of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K.ORCID 0000-0002-9730-0960
Nicholas E FisherCentre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K.
W David HongDepartment of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K.ORCID 0000-0002-0030-3007
Suet C LeungDepartment of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K.
Ghaith AljayyoussiCentre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K.
Jaclyn BibbyDepartment of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K.
Deepak V AlmeidaCenter for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland21205, United States.
Paul J ConverseCenter for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland21205, United States.
Nader FotouhiGlobal Alliance for TB Drug Development, New York, New York10005, United States.
Neil G BerryDepartment of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K.
Eric L NuermbergerCenter for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland21205, United States.
Anna M UptonGlobal Alliance for TB Drug Development, New York, New York10005, United States.ORCID 0000-0002-9522-1230
Paul M O'NeillDepartment of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K.ORCID 0000-0003-4338-0317
Stephen A WardCentre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K.
Giancarlo A BiaginiCentre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K.
Liverpool School of Tropical Medicine · GBUniversity of Liverpool · GBJohns Hopkins University · USTB Alliance · US
Funding
Medical Research Council MC_PC_17167Medical Research Council MR/L000644/1Medical Research Council MR/N028376/1Medical Research Council MR/S00467X/1Medical Research Council MR/W004356/1Wellcome Trust
Abstract
PubMed holds no abstract for this paper.
Indexed as
Antitubercular AgentsMycobacterium tuberculosisQuinolonesCytochromesElectron Transport Complex IVAntitubercular AgentsCytochromesElectron Transport Complex IVQuinolonesbedaquilinecytochrome bd oxidaseQ203tuberculosis
Identifiers
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Textmetadata
LicenceCC BY-NC-ND
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.