ArticleJournal of the European Academy of Dermatology and Venereology : JEADV2023
The association between atopic eczema and lymphopenia: Results from a UK cohort study with replication in US survey data.
Article in Journal of the European Academy of Dermatology and Venereology : JEADV, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Immunochemical Markers and Quality of Life in Severe Atopic Dermatitis: A Real-World Analysis.Journal of Korean medical science · 2026Article
- Polygenic transcriptome risk scores enhance predictive accuracy in atopic dermatitis.Journal of translational medicine · 2025Article
- IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice.International journal of molecular sciences · 2023Article
- The association between atopic eczema and lymphopenia: Results from a UK cohort study with replication in US survey data.Journal of the European Academy of Dermatology and Venereology : JEADV · 2023Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
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Abstract
backgroundLymphocyte skin homing in atopic eczema (AE) may induce lymphopenia.
objectiveTo determine if AE is associated with lymphopenia.
methodsWe used UK primary care electronic health records (Clinical Practice Research Datalink GOLD) for a matched cohort study in adults (18 years+) (1997-2015) with at least one recorded lymphocyte count. We matched people with AE to up to five people without. We used multivariable logistic regression to estimate the association between AE and lymphopenia (two low lymphocyte counts within 3 months) and linear mixed effects regression to estimate the association with absolute lymphocyte counts using all available counts. Cox proportional hazard models were used to investigate the effect of lymphopenia on common infections. We replicated the study using US survey data (National Health and Nutrition Examination Survey [NHANES]).
resultsAmong 71,731 adults with AE and 126,349 adults without AE, we found an adjusted odds ratio (OR) for lymphopenia of 1.16 (95% CI: 1.09-1.23); the strength of association increased with increasing eczema severity. When comparing all recorded lymphocyte counts from adults with AE (n = 1,497,306) to those of people without AE (n = 4,035,870) we saw a lower mean lymphocyte (adjusted mean difference -0.047 × 10
conclusionAtopic eczema, including increasing AE severity, is associated with a decreased lymphocyte count, regardless of immunosuppressive drug use. Whether the lower lymphocyte count has wider health implications for people with severe eczema warrants further investigation.
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