Evidence map›Paper›PMID 36606332›Full record

ArticleJournal of biomedical materials research. Part A2023

High porosity PEG-based hydrogel foams with self-tuning moisture balance as chronic wound dressings.

Ziyang Lan, Ronit Kar, Malgorzata Chwatko, Erik Shoga, Elizabeth Cosgriff-Hernandez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part A, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ziyang LanDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.ORCID 0000-0001-7935-137X
Ronit KarDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.
Malgorzata ChwatkoDepartment of Chemical and Materials Engineering, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-2770-5196
Erik ShogaDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.
Elizabeth Cosgriff-HernandezDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.
The University of Texas at Austin · USUniversity of Kentucky · US

Funding

Antimicrobial Hydrogel Foam Dressings for Infected Chronic WoundsR21AR076107 · NIAMS · UNIVERSITY OF TEXAS AT AUSTIN · PI COSGRIFF-HERNANDEZ, ELIZABETH MARIE · 2020 to 2021
$367k
NIAMS NIH HHS R21 AR076107
6 · The paper itself

Abstract

A major challenge in chronic wound treatment is maintaining an appropriate wound moisture balance throughout the healing process. Wound dehydration hinders wound healing due to impeded molecule transport and cell migration with associated tissue necrosis. In contrast, wounds that produce excess fluid contain high levels of reactive oxygen species and matrix metalloproteases that impede cell recruitment, extracellular matrix reconstruction, and angiogenesis. Dressings are currently selected based on the relative amount of wound exudate with no universal dressing available that can maintain appropriate wound moisture balance to enhance healing. This work aimed to develop a high porosity poly(ethylene glycol) diacrylate hydrogel foam that can both rapidly remove exudate and provide self-tuning moisture control to prevent wound dehydration. A custom foaming device was used to vary hydrogel foam porosity from 25% to 75% by adjusting the initial air-to-solution volume ratio. Hydrogel foams demonstrated substantial improvements in water uptake volume and rate as compared to bulk hydrogels while maintaining similar hydration benefits with slow dehydration rates. The hydrogel foam with the highest porosity (~75%) demonstrated the greatest water uptake and rate, which outperformed commercial dressing products, Curafoam® and Silvercel®, in water absorption, moisture retention, and exudate management. Investigation of the water vapor transmission rates of each dressing at varied hydration levels was characterized and demonstrated the dynamic moisture-controlling capability of the hydrogel foam dressing. Overall, the self-tuning moisture control of this hydrogel foam dressing holds great promise to improve healing outcomes for both dry and exudative chronic wounds.

Indexed as

BandagesDehydrationBiocompatible MaterialsHumansHydrogelsPolyethylene GlycolsPorosityBiocompatible MaterialsHydrogelspoly(ethylene glycol)diacrylatePolyethylene Glycolschronic woundsexudate managementhydrogel foammoisture balancewound dressing

Identifiers

PMID36606332
PMCPMC11542385
OpenAlexW4313646882

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.