Evidence map›Paper›PMID 36606270›Full record

ArticleAging medicine (Milton (N.S.W))2022

A pilot randomized controlled trial of WeiNaoKang (SaiLuoTong) in treating vascular dementia.

Junguang Liu, Dennis Chang, Dennis Cordato, Kien Lee, Hugh Dixson, Alan Bensoussan, Daniel Kam Yin Chan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging medicine (Milton (N.S.W)), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Subcutaneous application ofFrontiers in public health · 2026
    Observational
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Junguang LiuNICM Health Research Institute Western Sydney University Westmead New South Wales Australia.
Dennis ChangNICM Health Research Institute Western Sydney University Westmead New South Wales Australia.
Dennis CordatoDepartment of Neurology Liverpool Hospital Liverpool New South Wales Australia.
Kien LeeDepartment of Nuclear Medicine and Ultrasound Bankstown-Lidcombe Hospital Bankstown New South Wales Australia.
Hugh DixsonDepartment of Nuclear Medicine and Ultrasound Bankstown-Lidcombe Hospital Bankstown New South Wales Australia.
Alan BensoussanNICM Health Research Institute Western Sydney University Westmead New South Wales Australia.
Daniel Kam Yin ChanNICM Health Research Institute Western Sydney University Westmead New South Wales Australia.ORCID https://orcid.org/0000-0003-0481-3933

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: WeiNaoKang (or SaiLuoTong) is an herbal formula consisting of ginkgo, ginseng, and saffron. Our objective was to investigate if WeiNaoKang could improve cognitive function and cerebral perfusion in patients suffering from vascular dementia. Methods: A 16-week randomized double-blind, placebo-controlled trial was carried out in the setting of a memory disorder clinic at a single center. Patients with vascular dementia diagnosed clinically but supported by imaging and other investigations were invited to participate. The diagnoses were based on the National Institute of Neurological Disorders and Stroke/Association Internationale pour la Recherche et l'Enseignement en Neurosciences (NINDS-AIREN) criteria. An independent blinded assessor evaluated the effects of the formula. Intervention group was compared to the control group. A subgroup of participants was randomly chosen for further evaluation of cerebral perfusion by single photon emission computed tomography scans post-treatment. Results: Both groups were comparable in age (mean = 74 ± 7.2 years in the placebo group and 75 ± 7.4 in the intervention group) and in other demographics. Sixty-two participants were included in final analysis. Alzheimer's Disease Assessment Scale - Cognitive Portion (ADAS-cog) was the primary outcome. By week 16, the mean ADAS-cog reduced from 24.48 to 20.30 (mean reduction = 4.18) for those in the treatment group, and from 18.98 to 17.81 (mean reduction = 1.18) for those in the placebo group. The difference in mean reduction of ADAS-cog was -3.00 (95% confidence interval [CI] = -4.910 to -1.100) in favor of the treatment group. Secondary outcomes of activities of daily living and quality of life measures also showed significant difference. In the perfusion scan analysis, the difference in the change in cerebral blood flow (t-scores) pre- and post-treatment between the intervention group (n = 7) and the placebo group (n = 11) was statistically significant ( Conclusion: In this randomized, double-blind placebo-controlled trial, we demonstrated significant differences in improvement in cognitive function and activities of daily living. The clinical improvement is corroborated with improvement in cerebral perfusion in a subset of participants.

Indexed as

cerebral perfusion scandementiarandomized controlled trialSaiLuoTongvascular dementiaWeiNaoKang

Identifiers

PMID36606270
PMCPMC9805291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.