Evidence map›Paper›PMID 36606252›Full record

ReviewBioactive materials2023

Immune response differences in degradable and non-degradable alloy implants.

Taravat Khodaei, Elizabeth Schmitzer, Abhirami P Suresh, Abhinav P Acharya

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Taravat KhodaeiBiomedical Engineering, School of Biological and Health System Engineering, Arizona State, University, Tempe, AZ, 85281, USA.
Elizabeth SchmitzerBiomedical Engineering, School of Biological and Health System Engineering, Arizona State, University, Tempe, AZ, 85281, USA.
Abhirami P SureshBiological Design, Arizona State University, Tempe, AZ, 85281, USA.
Abhinav P AcharyaBiomedical Engineering, School of Biological and Health System Engineering, Arizona State, University, Tempe, AZ, 85281, USA.

Funding

Biomaterials-based metabolic rescue of dendritic cells for vaccine designR01AI155907 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ACHARYA, ABHINAV · 2021 to 2025
$1.7M
Local immunometabolism modulating biomaterials for immunosuppressive applicationsR01AR078343 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI ACHARYA, ABHINAV · 2021 to 2025
$1.6M
DMS/NIGMS 1: An Experimental Mathematical Framework for understanding and Controlling Regulatory Delay in Self- Nonself Determination in the Immune System R01GM144966 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI PEET, MATTHEW M · 2021 to 2023
$600k
NIAID NIH HHS R01 AI155907NIAMS NIH HHS R01 AR078343NIGMS NIH HHS R01 GM144966
6 · The paper itself

Abstract

Alloy based implants have made a great impact in the clinic and in preclinical research. Immune responses are one of the major causes of failure of these implants in the clinic. Although the immune responses toward non-degradable alloy implants are well documented, there is a poor understanding of the immune responses against degradable alloy implants. Recently, there have been several reports suggesting that degradable implants may develop substantial immune responses. This phenomenon needs to be further studied in detail to make the case for the degradable implants to be utilized in clinics. Herein, we review these new recent reports suggesting the role of innate and potentially adaptive immune cells in inducing immune responses against degradable implants. First, we discussed immune responses to allergen components of non-degradable implants to give a better overview on differences in the immune response between non-degradable and degradable implants. Furthermore, we also provide potential areas of research that can be undertaken that may shed light on the local and global immune responses that are generated in response to degradable implants.

Identifiers

PMID36606252
PMCPMC9793227

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.