Evidence map›Paper›PMID 36606188›Full record

ArticleJournal of Cancer2022

Mi Jeong Hong, Ji Eun Park, Shin Yup Lee, Jang Hyuck Lee, Jin Eun Choi, Hyo-Gyoung Kang, Sook Kyung Do, Ji Yun Jeong, Kyung Min Shin, Won Ki Lee and 9 more

Open access · goldAbstract read
In one paragraph

Article in Journal of Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Mi Jeong HongDepartment of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Ji Eun ParkDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Shin Yup LeeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jang Hyuck LeeDepartment of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jin Eun ChoiDepartment of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Hyo-Gyoung KangDepartment of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Sook Kyung DoDepartment of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Ji Yun JeongDepartment of Pathology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Kyung Min ShinDepartment of Radiology School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Won Ki LeeMedical Research Collaboration Center in Kyungpook National University Hospital and School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Yangki SeokDepartment of Thoracic Surgery, Soonchunhyang University Gumi Hospital, Gumi, Korea.
Sun Ha ChoiDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Yong Hoon LeeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Hyewon SeoDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Seung Soo YooDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jaehee LeeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Seung Ick ChaDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Chang Ho KimDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jae Yong ParkDepartment of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Kyungpook National University · KRKyungpook National University Hospital · KRSoonchunhyang University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pemetrexed is an anti-folate agent which is one of the most frequently used chemotherapy agents for non-squamous non-small cell lung cancer (NSCLC) patients. However, clinical response to pemetrexed chemotherapy and survival outcome of patients varies significantly. We evaluated whether the genetic variants in miRNA target sites may affect the treatment outcome of pemetrexed chemotherapy in lung adenocarcinoma patients. One hundred SNPs in miRNA binding regions in cancer-related genes were obtained from the crosslinking, ligation, and sequencing of hybrids (CLASH) and CancerGenes database, and the associations with the response to pemetrexed chemotherapy and survival outcomes were investigated in 314 lung adenocarcinoma patients. Two polymorphisms,

Indexed as

chemotherapygenetic variantslung adenocarcinomamiRNA target sitesresponsesurvival

Identifiers

PMID36606188
PMCPMC9809306
OpenAlexW4312229596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.