ArticleNetwork neuroscience (Cambridge, Mass.)2022
Network controllability mediates the relationship between rigid structure and flexible dynamics.
Article in Network neuroscience (Cambridge, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Association-sensory spatiotemporal hierarchy and functional gradient-regularised recurrent neural network with implications for schizophrenia.NPJ systems biology and applications · 2026Article
- HONeD-in on Brain Activity: Deconvolving Passive Diffusion on the Structural Network from Functional Brain Signals.bioRxiv : the preprint server for biology · 2026Article
- Disrupted Energetic and Entropic Landscape in Individuals With Mild Cognitive Impairment: Insights From Network Control Theory.Human brain mapping · 2025Article
- Task-Related Controllability of Functional Connectome During a Working Memory Task in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder.Research (Washington, D.C.) · 2025Article
- Emergence and reconfiguration of modular structure for artificial neural networks during continual familiarity detection.Science advances · 2024Article
- Macroscale coupling between structural and effective connectivity in the mouse brain.Scientific reports · 2024Article
- A new causal centrality measure reveals the prominent role of subcortical structures in the causal architecture of the extended default mode network.Brain structure & function · 2023Article
- Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex.Nature communications · 2023Article
- Larger lesion volume in people with multiple sclerosis is associated with increased transition energies between brain states and decreased entropy of brain activity.Network neuroscience (Cambridge, Mass.) · 2023Article
- The expanding horizons of network neuroscience: From description to prediction and control.NeuroImage · 2022Review
- Cognitive Control as a Multivariate Optimization Problem.Journal of cognitive neuroscience · 2022Article
- Structure-function models of temporal, spatial, and spectral characteristics of non-invasive whole brain functional imaging.Frontiers in neuroscience · 2022Review
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Authors and funding
9 authors.
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Abstract
Precisely how the anatomical structure of the brain supports a wide range of complex functions remains a question of marked importance in both basic and clinical neuroscience. Progress has been hampered by the lack of theoretical frameworks explaining how a structural network of relatively rigid interareal connections can produce a diverse repertoire of functional neural dynamics. Here, we address this gap by positing that the brain's structural network architecture determines the set of accessible functional connectivity patterns according to predictions of network control theory. In a large developmental cohort of 823 youths aged 8 to 23 years, we found that the flexibility of a brain region's functional connectivity was positively correlated with the proportion of its structural links extending to different cognitive systems. Notably, this relationship was mediated by nodes' boundary controllability, suggesting that a region's strategic location on the boundaries of modules may underpin the capacity to integrate information across different cognitive processes. Broadly, our study provides a mechanistic framework that illustrates how temporal flexibility observed in functional networks may be mediated by the controllability of the underlying structural connectivity.
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