Evidence map›Paper›PMID 36605889›Full record

ArticleNetwork neuroscience (Cambridge, Mass.)2022

Connectomic analysis of Alzheimer's disease using percolation theory.

Parker Kotlarz, Juan C Nino, Marcelo Febo

Abstract read
In one paragraph

Article in Network neuroscience (Cambridge, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  8. Early path dominance as a principle for neurodevelopment.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Parker KotlarzDepartment of Materials Science and Engineering, University of Florida, Gainesville, FL, USA.ORCID https://orcid.org/0000-0003-3667-8908
Juan C NinoDepartment of Materials Science and Engineering, University of Florida, Gainesville, FL, USA.ORCID https://orcid.org/0000-0001-8256-0535
Marcelo FeboDepartment of Psychiatry, University of Florida, Gainesville, FL, USA.ORCID https://orcid.org/0000-0001-8981-4163

Funding

Upgrade of an 11T/40cm MRI/S SystemS10RR025671 · NCRR · UNIVERSITY OF FLORIDA · PI EDISON, ARTHUR S · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025671
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a severe neurodegenerative disorder that affects a growing worldwide elderly population. Identification of brain functional biomarkers is expected to help determine preclinical stages for targeted mechanistic studies and development of therapeutic interventions to deter disease progression. Connectomic analysis, a graph theory-based methodology used in the analysis of brain-derived connectivity matrices was used in conjunction with percolation theory targeted attack model to investigate the network effects of AD-related amyloid deposition. We used matrices derived from resting-state functional magnetic resonance imaging collected on mice with extracellular amyloidosis (TgCRND8 mice,

Indexed as

Alzheimer’s diseaseBiomarkerConnectomicsfMRIGraph theoryPercolation theory

Identifiers

PMID36605889
PMCPMC9810282

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.