Evidence map›Paper›PMID 36605888›Full record

ArticleNetwork neuroscience (Cambridge, Mass.)2022

Bridging physiological and perceptual views of autism by means of sampling-based Bayesian inference.

Rodrigo Echeveste, Enzo Ferrante, Diego H Milone, Inés Samengo

Abstract read
In one paragraph

Article in Network neuroscience (Cambridge, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rodrigo EchevesteResearch Institute for Signals, Systems, and Computational Intelligence sinc(i) (FICH-UNL/CONICET), Santa Fe, Argentina.ORCID https://orcid.org/0000-0002-6155-8679
Enzo FerranteResearch Institute for Signals, Systems, and Computational Intelligence sinc(i) (FICH-UNL/CONICET), Santa Fe, Argentina.ORCID https://orcid.org/0000-0002-8500-788X
Diego H MiloneResearch Institute for Signals, Systems, and Computational Intelligence sinc(i) (FICH-UNL/CONICET), Santa Fe, Argentina.ORCID https://orcid.org/0000-0003-2182-4351
Inés SamengoMedical Physics Department and Balseiro Institute (CNEA-UNCUYO/CONICET), Bariloche, Argentina.ORCID https://orcid.org/0000-0002-5241-3697

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Theories for autism spectrum disorder (ASD) have been formulated at different levels, ranging from physiological observations to perceptual and behavioral descriptions. Understanding the physiological underpinnings of perceptual traits in ASD remains a significant challenge in the field. Here we show how a recurrent neural circuit model that was optimized to perform sampling-based inference and displays characteristic features of cortical dynamics can help bridge this gap. The model was able to establish a mechanistic link between two descriptive levels for ASD: a physiological level, in terms of inhibitory dysfunction, neural variability, and oscillations, and a perceptual level, in terms of hypopriors in Bayesian computations. We took two parallel paths-inducing hypopriors in the probabilistic model, and an inhibitory dysfunction in the network model-which lead to consistent results in terms of the represented posteriors, providing support for the view that both descriptions might constitute two sides of the same coin.

Indexed as

AutismHypopriorsInhibitory dysfunctionNeural circuitsSampling-based inference

Identifiers

PMID36605888
PMCPMC9810278

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.