Evidence map›Paper›PMID 36605800›Full record

ReviewNanoscale advances2022

Advanced nanomaterials for modulating Alzheimer's related amyloid aggregation.

Xu Shao, Chaoren Yan, Chao Wang, Chaoli Wang, Yue Cao, Yang Zhou, Ping Guan, Xiaoling Hu, Wenlei Zhu, Shichao Ding

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nanoscale advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Nanomedicine in the treatment of Alzheimer's disease: bypassing the blood-brain barrier with cutting-edge nanotechnology.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xu ShaoDepartment of Chemistry, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University 127 Youyi Road Xi'an 710072 China guanping1113@nwpu.edu.cn huxl@nwpu.edu.cn.ORCID https://orcid.org/0000-0002-4794-0441
Chaoren YanSchool of Medicine, Xizang Minzu University, Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region Xianyang Shaanxi 712082 China.ORCID https://orcid.org/0000-0002-5055-1893
Chao WangDepartment of Chemistry, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University 127 Youyi Road Xi'an 710072 China guanping1113@nwpu.edu.cn huxl@nwpu.edu.cn.
Chaoli WangDepartment of Pharmaceutical Chemistry and Analysis, School of Pharmacy, Air Force Medical University 169 Changle West Road Xi'an 710032 China.
Yue CaoSchool of the Environment, School of Chemistry and Chemical Engineering, State Key Laboratory of Analytical Chemistry for Life Science, State Key Laboratory of Pollution Control & Resource Reuse, Nanjing University Nanjing 210023 P. R. China wenleizhu@nju.edu.cn.
Yang ZhouKey Laboratory for Organic Electronics & Information Displays (KLOEID), Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications (NJUPT) Nanjing 210046 China.
Ping GuanDepartment of Chemistry, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University 127 Youyi Road Xi'an 710072 China guanping1113@nwpu.edu.cn huxl@nwpu.edu.cn.
Xiaoling HuDepartment of Chemistry, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University 127 Youyi Road Xi'an 710072 China guanping1113@nwpu.edu.cn huxl@nwpu.edu.cn.
Wenlei ZhuSchool of the Environment, School of Chemistry and Chemical Engineering, State Key Laboratory of Analytical Chemistry for Life Science, State Key Laboratory of Pollution Control & Resource Reuse, Nanjing University Nanjing 210023 P. R. China wenleizhu@nju.edu.cn.ORCID https://orcid.org/0000-0001-6110-993X
Shichao DingSchool of Mechanical and Materials Engineering, Washington State University Pullman WA 99164 USA shichao.ding@wsu.edu.ORCID https://orcid.org/0000-0003-3795-306X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a common neurodegenerative disease that brings about enormous economic pressure to families and society. Inhibiting abnormal aggregation of Aβ and accelerating the dissociation of aggregates is treated as an effective method to prevent and treat AD. Recently, nanomaterials have been applied in AD treatment due to their excellent physicochemical properties and drug activity. As a drug delivery platform or inhibitor, various excellent nanomaterials have exhibited potential in inhibiting Aβ fibrillation, disaggregating, and clearing mature amyloid plaques by enhancing the performance of drugs. This review comprehensively summarizes the advantages and disadvantages of nanomaterials in modulating amyloid aggregation and AD treatment. The design of various functional nanomaterials is discussed, and the strategies for improved properties toward AD treatment are analyzed. Finally, the challenges faced by nanomaterials with different dimensions in AD-related amyloid aggregate modulation are expounded, and the prospects of nanomaterials are proposed.

Identifiers

PMID36605800
PMCPMC9765474

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.