Evidence map›Paper›PMID 36605589›Full record

ArticleAnimal cells and systems2022

Protective effect of fermented aloe extract on glutamate-induced cytotoxicity in HT22 cells.

Ki Beom Jeon, Seong Hun Lee, Yong Seong Kwon, Jin Hong Beak, Hyeon Lee, Choong Je Ma

Open access · goldAbstract read
In one paragraph

Article in Animal cells and systems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Aloin attenuates NMDA receptor by modulating calcium response on substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026
    Article
  2. Hormesis: induction byOpen medicine (Warsaw, Poland) · 2026
    Review
  3. Article
  4. Neuroprotective effect of ropinirole against AβThe Kaohsiung journal of medical sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ki Beom JeonR&DB Center, Beauty Science, Ltd., Sejong, Korea.
Seong Hun LeeR&D center, KJM Aloe Co., Ltd., Seoul, Korea.
Yong Seong KwonR&D center, KJM Aloe Co., Ltd., Seoul, Korea.
Jin Hong BeakR&D center, KJM Aloe Co., Ltd., Seoul, Korea.
Hyeon LeeR&DB Center, Beauty Science, Ltd., Sejong, Korea.
Choong Je MaDepartment of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Chuncheon, South Korea.
Kangwon National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive glutamate can cause oxidative stress in neuronal cells and this can significantly contribute to the etiology of neurodegenerative disease. The present study mainly aims to investigate that aloe extract (AE) and fermented aloe extract (FAE) could protect against glutamate-induced cytotoxicity by modulating oxidative stress. In this study, both AE and FAE showed potent neuroprotective activity by inhibiting ROS and Ca

Indexed as

Aloe arborescensaloeninaloinneuroprotectionoxidative stress

Identifiers

PMID36605589
PMCPMC9809408
OpenAlexW4309707620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.