Evidence map›Paper›PMID 36605536›Full record

ArticleRespirology case reports2023

Immune-related aseptic meningitis diagnosed by Cube FLAIR on enhanced magnetic resonance imaging for a lung cancer patient administered atezolizumab: A case report.

Ryo Kuroda, Hiroaki Nakagawa, Yasuki Uchida, Keiko Narumiya, Yoko Tsunoda, Masafumi Yamaguchi, Tatsuya Oki, Shinnosuke Hiratsuka, Yukihiro Nagatani, Yasutaka Nakano

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Respirology case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ryo KurodaDivision of Respiratory Medicine, Department of Internal Medicine Shiga University of Medical Science Otsu Japan.ORCID https://orcid.org/0000-0002-7379-8899
Hiroaki NakagawaDivision of Respiratory Medicine, Department of Internal Medicine Shiga University of Medical Science Otsu Japan.ORCID https://orcid.org/0000-0003-3830-765X
Yasuki UchidaDivision of Respiratory Medicine, Department of Internal Medicine Shiga University of Medical Science Otsu Japan.
Keiko NarumiyaDivision of Respiratory Medicine, Department of Internal Medicine Shiga University of Medical Science Otsu Japan.
Yoko TsunodaDivision of Respiratory Medicine, Department of Internal Medicine Shiga University of Medical Science Otsu Japan.
Masafumi YamaguchiDivision of Respiratory Medicine, Department of Internal Medicine Shiga University of Medical Science Otsu Japan.
Tatsuya OkiDepartment of Radiology Shiga University of Medical Science Otsu Japan.
Shinnosuke HiratsukaDepartment of Radiology Shiga University of Medical Science Otsu Japan.
Yukihiro NagataniDepartment of Radiology Shiga University of Medical Science Otsu Japan.
Yasutaka NakanoDivision of Respiratory Medicine, Department of Internal Medicine Shiga University of Medical Science Otsu Japan.
Shiga University of Medical Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), such as neurological toxicity. A 46-year-old man was diagnosed with squamous cell lung cancer. Lung cancer recurred 3 years after he experienced left segmental lung rejection. Therefore, he received atezolizumab as fourth-line chemotherapy. He experienced fever, headache, and decreased consciousness 10 days after the first dose of atezolizumab. Plain head computed tomography and cerebrospinal fluid examination showed no significant findings. Magnetic resonance imaging (MRI) with a Gadolinium (Gd)-enhanced Cube fluid-attenuated inversion recovery (FLAIR) sequence showed nodular abnormalities with contrast enhancement. Thus, aseptic meningitis caused by ICIs was suspected. His consciousness level gradually improved with glucocorticoid therapy. Moreover, most nodular abnormalities observed on cerebral MRI disappeared concurrently. Thus, Gd-enhanced Cube FLAIR sequence has the unique ability to reveal immune-related aseptic meningitis.

Indexed as

aseptic meningitisCube FLAIRimmune checkpoint inhibitorsimmune‐related adverse event

Identifiers

PMID36605536
PMCPMC9808141
OpenAlexW4313513888

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.