ArticleNetwork neuroscience (Cambridge, Mass.)2022
Percolation may explain efficiency, robustness, and economy of the brain.
Article in Network neuroscience (Cambridge, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- A methodological guideline for consciousness assessment via neural electrophysiological activity.Military Medical Research · 2025Guideline
- Relapse in alcohol dependence is characterized by disrupted modular brain network organization.European archives of psychiatry and clinical neuroscience · 2026Article
- Identifying omic biomarkers for chronic inflammatory diseases associated with periodontitis using percolation on multi-disease gene co-expression networks.Communications medicine · 2026Article
- Rules of life at the interface of calcium signaling and mechanobiology.APL bioengineering · 2025Review
- Martial arts induce quasicritical brain states: a unified, multiscale, and mechanistic theory of brain health optimization.Frontiers in psychology · 2025Article
- Both k-core percolation and directed graph analysis revealed succession and transition of voxels' spatiotemporal progress on dynamic correlation resting-state fMRI.Frontiers in human neuroscience · 2025Article
- Brain-like hardware, do we need it?Frontiers in neuroscience · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain consists of billions of neurons connected by ultra-dense synapses, showing remarkable efficiency, robust flexibility, and economy in information processing. It is generally believed that these advantageous properties are rooted in brain connectivity; however, direct evidence remains absent owing to technical limitations or theoretical vacancy. This research explores the origins of these properties in the largest yet brain connectome of the fruit fly. We reveal that functional connectivity formation in the brain can be explained by a percolation process controlled by synaptic excitation-inhibition (E/I) balance. By increasing the E/I balance gradually, we discover the emergence of these properties as byproducts of percolation transition when the E/I balance arrives at 3:7. As the E/I balance keeps increase, an optimal E/I balance 1:1 is unveiled to ensure these three properties simultaneously, consistent with previous in vitro experimental predictions. Once the E/I balance reaches over 3:2, an intrinsic limitation of these properties determined by static (anatomical) brain connectivity can be observed. Our work demonstrates that percolation, a universal characterization of critical phenomena and phase transitions, may serve as a window toward understanding the emergence of various brain properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.