Evidence map›Paper›PMID 36605018›Full record

ArticleProtein science : a publication of the Protein Society2023

Distinct conformational changes occur within the intrinsically unstructured pro-domain of pro-Nerve Growth Factor in the presence of ATP and Mg

Francesca Paoletti, Sonia Covaceuszach, Alberto Cassetta, Antonio N Calabrese, Urban Novak, Petr Konarev, Jože Grdadolnik, Doriano Lamba, Simona Golič Grdadolnik

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Francesca PaolettiLaboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Ljubljana, Slovenia.ORCID 0000-0002-1527-5088
Sonia CovaceuszachInstitute of Crystallography-C.N.R.-Trieste Outstation, Trieste, Italy.ORCID 0000-0001-7453-1099
Alberto CassettaInstitute of Crystallography-C.N.R.-Trieste Outstation, Trieste, Italy.ORCID 0000-0002-8600-4162
Antonio N CalabreseSchool of Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.ORCID 0000-0003-2437-7761
Urban NovakLaboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Ljubljana, Slovenia.
Petr KonarevA.V. Shubnikov Institute of Crystallography of Federal Scientific Research Centre "Crystallography and Photonics", Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0002-5606-1596
Jože GrdadolnikLaboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Ljubljana, Slovenia.ORCID 0000-0002-0312-168X
Doriano LambaInstitute of Crystallography-C.N.R.-Trieste Outstation, Trieste, Italy.ORCID 0000-0001-6859-7868
Simona Golič GrdadolnikLaboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Ljubljana, Slovenia.ORCID 0000-0002-0873-9593
National Institute of Chemistry · SIInstitute of Crystallography · ITRussian Academy of Sciences · RUUniversity of Leeds · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M012573/1Wellcome Trust 220628
6 · The paper itself

Abstract

Nerve growth factor (NGF), the prototypical neurotrophic factor, is involved in the maintenance and growth of specific neuronal populations, whereas its precursor, proNGF, is involved in neuronal apoptosis. Binding of NGF or proNGF to TrkA, p75

Indexed as

Nerve Growth FactorNeuronsAdenosine TriphosphateProtein DomainsAdenosine TriphosphateNerve Growth Factorconformational rearrangement of the Intrinsically Unstructured Domain (IUD)Hydrogen-Deuterium eXchange-Mass Spectrometry (HDX-MS)intermolecular interactionsNMR spectroscopyproNGFSmall Angle X-ray Scattering (SAXS)

Identifiers

PMID36605018
PMCPMC9878617
OpenAlexW4313640836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.