Evidence map›Paper›PMID 36604600›Full record

ArticleCommunications biology2023

Spectrin-beta 2 facilitates the selective accumulation of GABA

Joshua L Smalley, Noell Cho, Shu Fun Josephine Ng, Catherine Choi, Abigail H S Lemons, Saad Chaudry, Christopher E Bope, Jake S Dengler, Chuansheng Zhang, Matthew N Rasband and 2 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Joshua L SmalleyDepartment of Neuroscience, Tufts University, Boston, MA, 02111, USA.
Noell ChoDepartment of Neuroscience, Tufts University, Boston, MA, 02111, USA.
Shu Fun Josephine NgDepartment of Neuroscience, Tufts University, Boston, MA, 02111, USA.
Catherine ChoiDepartment of Neuroscience, Tufts University, Boston, MA, 02111, USA.ORCID 0000-0002-3215-9601
Abigail H S LemonsDepartment of Neuroscience, Tufts University, Boston, MA, 02111, USA.
Saad ChaudryDepartment of Neuroscience, Tufts University, Boston, MA, 02111, USA.
Christopher E BopeDepartment of Neuroscience, Tufts University, Boston, MA, 02111, USA.
Jake S DenglerDepartment of Neuroscience, Tufts University, Boston, MA, 02111, USA.
Chuansheng ZhangDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, 76706, USA.
Matthew N RasbandDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, 76706, USA.ORCID 0000-0001-8184-2477
Paul A DaviesDepartment of Neuroscience, Tufts University, Boston, MA, 02111, USA.
Stephen J MossDepartment of Neuroscience, Tufts University, Boston, MA, 02111, USA. Stephen.Moss@tufts.edu.
Tufts University · USBaylor College of Medicine · US

Funding

The Synthesis of GABA in Epileptic BrainP01NS054900 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI COULTER, DOUGLAS A · 2007 to 2011
$6.4M
Studies on the structure of gamma-aminobutyric acid type A receptor subtypesR01MH118263 · NIMH · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2019 to 2023
$2.4M
Modulation of KCC2 activity and the postnatal development of synaptic inhibitionR01NS101888 · NINDS · TUFTS UNIVERSITY BOSTON · PI DEEB, TAREK ZIAD, MOSS, STEPHEN J · 2017 to 2021
$2.3M
Novel actions of neurosteroids on GABA (A) receptor traffickingR01MH097446 · NIMH · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2013 to 2017
$2.1M
Novel actions of neurosteroids on GABA (A) receptor traffickingR01NS108378 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2018 to 2022
$2.0M
Studies on G-protein coupled receptors that are activated by neuroactive steroidsR01MH137022 · NIMH · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2024 to 2024
$564k
Mechanisms that determine the activity of glutamine synthetase in the brainR21NS103865 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2018 to 2019
$454k
Determining the effects of human KCC2 mutations on neuronal excitabilityR21NS111338 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW · 2019 to 2020
$454k
NIMH NIH HHS R01 MH097446NIMH NIH HHS R01 MH137022NINDS NIH HHS P01 NS054900U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH118263U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS101888U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS103865U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS108378U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS111338
6 · The paper itself

Abstract

Fast synaptic inhibition is dependent on targeting specific GABA

Indexed as

Receptors, GABA-ASpectringamma-Aminobutyric AcidMembrane ProteinsSynapsesgamma-Aminobutyric AcidMembrane ProteinsReceptors, GABA-ASpectrin

Identifiers

PMID36604600
PMCPMC9816108
OpenAlexW4313557951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.