Evidence map›Paper›PMID 36604578›Full record

ArticleScientific reports2023

Residential green environments are associated with human milk oligosaccharide diversity and composition.

Mirkka Lahdenperä, Laura Galante, Carlos Gonzales-Inca, Jussi Vahtera, Jaana Pentti, Samuli Rautava, Niina Käyhkö, Chloe Yonemitsu, Julia Gupta, Lars Bode and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mirkka LahdenperäDepartment of Biology, University of Turku, Turku, Finland. Mirkka.Lahdenpera@utu.fi.ORCID 0000-0003-0062-6284
Laura GalanteDepartment of Biology, University of Turku, Turku, Finland.ORCID 0000-0002-6190-7955
Carlos Gonzales-IncaDepartment of Geography and Geology, University of Turku, Turku, Finland.ORCID 0000-0003-0300-9097
Jussi VahteraDepartment of Public Health, University of Turku and Turku University Hospital, Turku, Finland.ORCID 0000-0002-6036-061X
Jaana PenttiDepartment of Public Health, University of Turku and Turku University Hospital, Turku, Finland.
Samuli RautavaDepartment of Pediatrics, University of Turku, Turku, Finland.ORCID 0000-0003-0935-3593
Niina KäyhköDepartment of Geography and Geology, University of Turku, Turku, Finland.ORCID 0000-0003-2482-5085
Chloe YonemitsuDepartment of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), University of California San Diego, La Jolla, CA, USA.
Julia GuptaDepartment of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), University of California San Diego, La Jolla, CA, USA.
Lars BodeDepartment of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-9914-9571
Hanna LagströmDepartment of Public Health, University of Turku and Turku University Hospital, Turku, Finland.ORCID 0000-0002-5069-6582

Funding

Exploring Associations between Human Milk Oligosaccharides and Growth, Body Composition and Obesity Risk in Infancy and Early ChildhoodR21HD088953 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BODE, LARS · 2017 to 2018
$415k
NICHD NIH HHS R21 HD088953
6 · The paper itself

Abstract

Increased exposure to greener environments has been suggested to lead to health benefits in children, but the associated mechanisms in early life, particularly via biological mediators such as altered maternal milk composition, remain largely unexplored. We investigated the associations between properties of the mother's residential green environment, measured as (1) greenness (Normalized Difference Vegetation index, NDVI), (2) Vegetation Cover Diversity (VCDI) and (3) Naturalness Index (NI), and human milk oligosaccharides (HMOs), known for their immune- and microbiota-related health effects on the infant (N = 795 mothers). We show that HMO diversity increases and concentrations of several individual HMOs and HMO groups change with increased VCDI and NI in residential green environments. This suggests that variation in residential green environments may influence the infant via maternal milk through modified HMO composition. The results emphasize the mediating role of breastfeeding between the residential green environments and health in early life.

Indexed as

MicrobiotaMilk, HumanBreast FeedingChildFemaleHumansInfantMothersOligosaccharidesOligosaccharides

Identifiers

PMID36604578
PMCPMC9816313

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.