Evidence map›Paper›PMID 36604452›Full record

ArticleScientific data2023

Single-nucleus profiling of adult mice sub-ventricular zone after blast-related traumatic brain injury.

Manrui Li, Xiameng Chen, Qiuyun Yang, Shuqiang Cao, Steven Wyler, Ruixuan Yuan, Lingxuan Zhang, Miao Liao, Meili Lv, Feng Wang and 5 more

Erratum issuedAbstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Manrui Li *Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, Shanghai, 200000, China.
Xiameng Chen *Department of Forensic Pathology and Forensic Clinical Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, 610041, China.
Qiuyun YangDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, 610041, China.
Shuqiang CaoDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, 610041, China.
Steven WylerDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Ruixuan YuanSichuan University, Chengdu, 610041, China.
Lingxuan ZhangSichuan University, Chengdu, 610041, China.
Miao LiaoDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, 610041, China.
Meili LvDepartment of Immunology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, 610041, China.
Feng WangDepartment of Medical Oncology, Cancer Center, Sichuan University, Chengdu, 610041, China.
Yadong GuoDepartment of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha, Hunan, 410013, China.
Jihong ZhouArmy Medical University, Chongqing, 404000, China. traumazjh@126.com.
Lin ZhangSichuan University, Chengdu, 610041, China. zhanglin@scu.edu.cn.
Xiaoqi XieDepartment of Critical Care Medicine, Sichuan University, Chengdu, 610041, China. xiaoqixie1898060@163.com.
Weibo LiangDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, 610041, China. liangweibo@gmail.com.ORCID http://orcid.org/0000-0002-8487-3575

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Explosive blast-related traumatic brain injuries (bTBI) are common in war zones and urban terrorist attacks. These bTBIs often result in complex neuropathologic damage and neurologic complications. However, there is still a lack of specific strategies for diagnosing and/or treating bTBIs. The sub-ventricular zone (SVZ), which undergoes adult neurogenesis, is critical for the neurological maintenance and repair after brain injury. However, the cellular responses and mechanisms that trigger and modulate these activities in the pathophysiological processes following bTBI remain poorly understood. Here we employ single-nucleus RNA-sequencing (snRNA-seq) of the SVZ from mice subjected to a bTBI. This data-set, including 15272 cells (7778 bTBI and 7494 control) representing all SVZ cell types and is ideally suited for exploring the mechanisms underlying the pathogenesis of bTBIs. Additionally, it can serve as a reference for future studies regarding the diagnosis and treatment of bTBIs.

Indexed as

Blast InjuriesBrain InjuriesBrain Injuries, TraumaticAnimalsMice

Identifiers

PMID36604452
PMCPMC9814753

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.