ArticleSchizophrenia (Heidelberg, Germany)2023
Progressive brain abnormalities in schizophrenia across different illness periods: a structural and functional MRI study.
Article in Schizophrenia (Heidelberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Magnetic resonance imaging-based machine learning classification of schizophrenia spectrum disorders: a meta-analysis.Psychiatry and clinical neurosciences · 2024Pooled it
- Decoding Psychosis Risk: Neuroanatomical Correlates of the NAPLS-2 Calculator in the PRONIA Cohort.Schizophrenia bulletin · 2026Article
- Structural alteration of neurons in schizophrenia and its relation with auditory hallucination.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- MiR-7 in neurological disorders: beyond metabolic dysregulation.Frontiers in neuroscience · 2026Review
- Temporal integration window of sensory processing as a neuropsychological marker for clinical high risk of psychosis.Schizophrenia (Heidelberg, Germany) · 2025Article
- MesoSCOUT: A novel tool for revealing mesoscale organization in the white-matter connectome.bioRxiv : the preprint server for biology · 2025Article
- Identifying key brain pathology in bipolar and unipolar depression using a region-specific brain aging trajectories approach: Insights from the Taiwan Aging and Mental Illness Cohort.Psychological medicine · 2025Article
- [Illness duration-related developmental trajectory of progressive cerebral gray matter changes in schizophrenia].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Characterizing multivariate regional hubs for schizophrenia classification, sex differences, and brain age estimation using explainable AI.medRxiv : the preprint server for health sciences · 2025Article
- The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms.Journal of neuroinflammation · 2025Review
- Dynamic mode decomposition of resting-state fMRI revealing abnormal brain region features in schizophrenia.Frontiers in computational neuroscience · 2025Article
- Pulvinar and Ventral Thalamic Nuclei Changes Occur Early Along the Psychosis Spectrum.Schizophrenia bulletin open · 2025Article
- Low-frequency rTMS induces modifications in cortical structural connectivity - functional connectivity coupling in schizophrenia patients with auditory verbal hallucinations.Human brain mapping · 2024Article
- Neurostructural changes in schizophrenia and treatment-resistance: a narrative review.Psychoradiology · 2024Review
- Thoughtful Response on "MRI-based Texture Analysis for Preoperative Prediction ofJournal of multidisciplinary healthcare · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Schizophrenia is a chronic brain disorder, and neuroimaging abnormalities have been reported in different stages of the illness for decades. However, when and how these brain abnormalities occur and evolve remains undetermined. We hypothesized structural and functional brain abnormalities progress throughout the illness course at different rates in schizophrenia. A total of 115 patients with schizophrenia were recruited and stratified into three groups of different illness periods: 5-year group (illness duration: ≤5 years), 15-year group (illness duration: 12-18 years), and 25-year group (illness duration: ≥25 years); 230 healthy controls were matched by age and sex to the three groups, respectively. All participants underwent resting-state MRI scanning. Each group of patients with schizophrenia was compared with the corresponding controls in terms of voxel-based morphometry (VBM), fractional anisotropy (FA), global functional connectivity density (gFCD), and sample entropy (SampEn) abnormalities. In the 5-year group we observed only SampEn abnormalities in the putamen. In the 15-year group, we observed VBM abnormalities in the insula and cingulate gyrus and gFCD abnormalities in the temporal cortex. In the 25-year group, we observed FA abnormalities in nearly all white matter tracts, and additional VBM and gFCD abnormalities in the frontal cortex and cerebellum. By using two structural and two functional MRI analysis methods, we demonstrated that individual functional abnormalities occur in limited brain areas initially, functional connectivity and gray matter density abnormalities ensue later in wider brain areas, and structural connectivity abnormalities involving almost all white matter tracts emerge in the third decade of the course in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.