SynthesisNPJ primary care respiratory medicine2023
Systematic review and meta-analysis of prevalence, trajectories, and clinical outcomes for frailty in COPD.
Synthesis in NPJ primary care respiratory medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Frailty in COPD: Clinical Impact, Diagnosis, Biomarkers, and Management Strategies.International journal of chronic obstructive pulmonary disease · 2025Pooled it
- The frailty mortality link in people with chronic diseases pertaining to 13 body organ systems: findings from the UK Biobank study.GeroScience · 2026Article
- Association of Airway Mucus Plugs and Physical Activity, Exercise Tolerance, Sarcopenia, and Frailty in Patients With COPD and Pre-COPD.Respirology (Carlton, Vic.) · 2026Observational
- Article
- Article
- Frailty and COPD: a bidirectional relationship in the context of systemic and accelerated ageing.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Frailty Is a Predictor of Disability, Hospitalization and Mortality in Older Adults with COPD: A Longitudinal Study.Journal of clinical medicine · 2026Article
- Frailty and social, clinical and computed tomography imaging factors in COPD: a multicentre study.ERJ open research · 2026Article
- Development and validation of a clinical nomogram for frailty prediction in older COPD patients: a machine learning approach.BMC geriatrics · 2026Article
- Determinants of All-Cause Mortality in Spirometry-Confirmed COPD in Primary Care: A Population-Based Multidimensional Cohort Study.Journal of clinical medicine · 2026Article
- Change of frailty index and anthropometric indices in patients with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2026Article
- Patient-Caregiver Dyads in Severe and Advanced COPD: Relationships, Caregiving Burden, and Intervention Support: A Narrative Review.International journal of chronic obstructive pulmonary disease · 2026Review
- Prevalence, Persistence, and Agreement of Physical Frailty Tools in Patients with Severe COPD Declining Pulmonary Rehabilitation: An Exploratory 1-Year Prospective Cohort Study.Journal of clinical medicine · 2025Article
- Predictors of mortality and hospitalised exacerbations in obstructive airway diseases.ERJ open research · 2025Article
- Sarcopenia in chronic obstructive pulmonary disease: mechanisms, diagnosis, and management strategies.Annals of medicine and surgery (2012) · 2025Review
- Association between preserved ratio impaired spirometry and frailty risk among US adults: a cross-sectional study.BMJ open · 2025Article
- The Burden of COPD with Type 2 Inflammation in North-West Continental Europe.International journal of chronic obstructive pulmonary disease · 2025Review
- Identifying and Estimating Frailty Phenotypes by Vocal Biomarkers: Cross-Sectional Study.Journal of medical Internet research · 2024Article
- Comparison of two frailty definitions in women with systemic lupus erythematosus.Rheumatology (Oxford, England) · 2024Article
- Association between oxidative balance score and frailty in chronic obstructive pulmonary disease.Heliyon · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
This systematic review synthesised measurement and prevalence of frailty in COPD and associations between frailty and adverse health outcomes. We searched Medline, Embase and Web of Science (1 January 2001-8 September 2021) for observational studies in adults with COPD assessing frailty prevalence, trajectories, or association with health-related outcomes. We performed narrative synthesis and random-effects meta-analyses. We found 53 eligible studies using 11 different frailty measures. Most common were frailty phenotype (n = 32), frailty index (n = 5) and Kihon checklist (n = 4). Prevalence estimates varied by frailty definitions, setting, and age (2.6-80.9%). Frailty was associated with mortality (5/7 studies), COPD exacerbation (7/11), hospitalisation (3/4), airflow obstruction (11/14), dyspnoea (15/16), COPD severity (10/12), poorer quality of life (3/4) and disability (1/1). In conclusion, frailty is a common among people with COPD and associated with increased risk of adverse outcomes. Proactive identification of frailty may aid risk stratification and identify candidates for targeted intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.