ArticleWorld journal of pediatrics : WJP2023
Longer duration of initial invasive mechanical ventilation is still a crucial risk factor for moderate-to-severe bronchopulmonary dysplasia in very preterm infants: a multicentrer prospective study.
Article in World journal of pediatrics : WJP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Risk factors for bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis.PeerJ · 2025Pooled it
- Association of TNF-α genetic variants with neonatal bronchopulmonary dysplasia: consolidated results.Frontiers in pediatrics · 2024Pooled it
- The association between VEGF genetic variations and the risk of bronchopulmonary dysplasia in premature infants: a meta-analysis and systematic review.Frontiers in pediatrics · 2024Pooled it
- Higher (40%) versus lower (30%) FiOEuropean journal of pediatrics · 2025Trial
- Prediction of bronchopulmonary dysplasia seven days after birth using respiratory and oxygenation timeseries with machine learning.Pediatric research · 2026Article
- Outcomes and complications of invasive versus non-invasive respiratory support in extremely preterm infants: a retrospective study.BMC pediatrics · 2026Article
- Development and internal validation of a clinical nomogram for predicting bronchopulmonary dysplasia in preterm infants.Experimental and therapeutic medicine · 2026Article
- A three-factor nomogram predicts the use of invasive mechanical ventilation within 72 h in preterm infants.Frontiers in medicine · 2026Article
- Incidence and factors associated with bronchopulmonary dysplasia: a cohort study in a high-risk Colombian neonatal intensive care unit.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2026Observational
- Bridging evidence and practice: implementation science and bundled care strategies for fluid management in critically ill neonates.Frontiers in medicine · 2026Article
- Development and validation of machine learning models for predicting bronchopulmonary dysplasia risk in preterm neonates based on antenatal determinants: a retrospective cohort study.BMC pediatrics · 2025Article
- Antenatal Corticosteroids and Bronchopulmonary Dysplasia in Very Preterm Infants.JAMA network open · 2025Article
- The Chinese adverse prognosis of very preterm infants (CARE-Preterm) cohort: study design and baseline characteristics for a prospective multicenter cohort study.BMC pediatrics · 2025Article
- The current clinical landscape of preterm infants less than 32 weeks of gestation receiving delivery room chest compression in Jiangsu Province, China.Resuscitation plus · 2025Article
- Analysis of the Levels of CD40L and NGAL in Umbilical Cord Blood of Preterm Infants with Moderate to Severe Bronchopulmonary Dysplasia and Their Clinical Value: A Single-Center Retrospective Study.Pediatric health, medicine and therapeutics · 2025Article
- Article
- Clinical features, pathogens, and prognosis of immunocompromised host pneumonia in patients with malignancies.Frontiers in cellular and infection microbiology · 2025Article
- Impact of early caffeine administration on respiratory outcomes in very preterm infants initially receiving invasive mechanical ventilation.BMJ open respiratory research · 2024Observational
- Right ventricular function indices and platelet parameters for early prediction value of bronchopulmonary dysplasia: a retrospective study.BMC pediatrics · 2024Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 13 institutions in 1 country.
Funding
Abstract
objectivesWe aimed to evaluate the risk factors for moderate-to-severe bronchopulmonary dysplasia (BPD) and focus on discussing its relationship with the duration of initial invasive mechanical ventilation (IMV) in very preterm neonates less than 32 weeks of gestational age (GA).
methodsWe performed a prospective cohort study involving infants born at 23-31 weeks of GA who were admitted to 47 different neonatal intensive care unit (NICU) hospitals in China from January 2018 to December 2021. Patient data were obtained from the Sina-northern Neonatal Network (SNN) Database.
resultsWe identified 6538 very preterm infants, of whom 49.5% (3236/6538) received initial IMV support, and 12.6% (823/6538) were diagnosed with moderate-to-severe BPD symptoms. The median duration of initial IMV in the moderate-to-severe BPD group was 26 (17-41) days, while in the no or mild BPD group, it was 6 (3-10) days. The incidence rate of moderate-to-severe BPD and the median duration of initial IMV were quite different across different GAs. Multivariable logistic regression analysis showed that the onset of moderate-to-severe BPD was significantly associated with the duration of initial IMV [adjusted odds ratio (AOR): 1.97; 95% confidence interval (CI): 1.10-2.67], late-onset neonatal sepsis (LONS), and patent ductus arteriosus (PDA).
conclusionIn this multicenter cohort study, the duration of initial IMV was still relatively long in very premature infants, and the longer duration of initial IMV accounts for the increased risk of moderate-to-severe BPD.
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