Evidence map›Paper›PMID 36604348›Full record

ArticleMolecular genetics and genomics : MGG2023

Role of PumB antitoxin as a transcriptional regulator of the PumAB type-II toxin-antitoxin system and its endoribonuclease activity on the PumA (toxin) transcript.

K C Hernández-Ramírez, M I Valle-Maldonado, J A Patiño-Medina, S Calo, I E Jácome-Galarza, V Garre, V Meza-Carmen, M I Ramírez-Díaz

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular genetics and genomics : MGG, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Insights into toxin-antitoxin systems in the genusApplied and environmental microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

K C Hernández-RamírezLaboratorio de Microbiología, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-3, Ciudad Universitaria, 58030, Morelia, Michoacán, Mexico.
M I Valle-MaldonadoLaboratorio de Diferenciación Celular, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria, 58030, Morelia, Michoacán, Mexico.
J A Patiño-MedinaLaboratorio de Diferenciación Celular, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria, 58030, Morelia, Michoacán, Mexico.
S CaloSchool of Natural and Exact Sciences, Pontificia Universidad Católica Madre y Maestra, 51033, Santiago de los Caballeros, Dominican Republic.
I E Jácome-GalarzaLaboratorio Estatal de Salud Pública, Secretaría de Salud Michoacán, Morelia, Mexico.
V GarreDepartamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100, Murcia, Spain.
V Meza-CarmenLaboratorio de Diferenciación Celular, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria, 58030, Morelia, Michoacán, Mexico.
M I Ramírez-DíazLaboratorio de Microbiología, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-3, Ciudad Universitaria, 58030, Morelia, Michoacán, Mexico. martha.ramirez@umich.mx.ORCID http://orcid.org/0000-0002-0125-346X
Universidad Michoacana de San Nicolás de Hidalgo · MXPontificia Universidad Católica Madre y Maestra · DOSecretaria de Salud · MXUniversidad de Murcia · ES

Funding

Consejo Nacional de Ciencia y Tecnologia, México 181747Consejo Nacional de Ciencia y Tecnología, Mexico 166071Consejo Nacional de Ciencia y Tecnología, México 2574566
6 · The paper itself

Abstract

The PumAB type-II toxin-antitoxin (TA) system is encoded by pumAB genes that are organized into an operon. This system is encoded by the pUM505 plasmid, isolated from a Pseudomonas aeruginosa clinical strain. The pumA gene encodes a putative RelE toxin protein (toxic component), whereas the pumB gene encodes a putative HTH antitoxin protein. The expression of the PumAB system in Escherichia coli confers plasmid stability. In addition, PumA toxin overexpression in P. aeruginosa possesses the capability to increase bacterial virulence, an effect that is neutralized by the PumB antitoxin. The aim of this study was to establish the mechanism of regulation of the PumAB toxin-antitoxin system from pUM505. By an in silico analysis of the putative regulatory elements, we identified two putative internal promoters, P

Indexed as

AntitoxinsBacterial ToxinsToxin-Antitoxin SystemsApoptosis Regulatory ProteinsBacterial ProteinsEndoribonucleasesEscherichia coliGene Expression Regulation, BacterialHumansRibonucleasesRNA, MessengerAntitoxinsApoptosis Regulatory ProteinsBacterial ProteinsBacterial ToxinsEndoribonucleasesRibonucleasesRNA, MessengerEndoribonuclease activityPseudomonas aeruginosaPumAB toxin–antitoxin systemTranscriptional regulator

Identifiers

PMID36604348
OpenAlexW4313561414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.