Evidence map›Paper›PMID 36604310›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2023

3D Printing of Self-Assembling Nanofibrous Multidomain Peptide Hydrogels.

Adam C Farsheed, Adam J Thomas, Brett H Pogostin, Jeffrey D Hartgerink

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. ACS nano · 2026
    Article
  6. Omnidirectional 3D Printing of Anisotropic Nanofibrous Peptide Hydrogels.bioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Advancing Synthetic Hydrogels through Nature-Inspired Materials Chemistry.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  16. Article
  17. Tunable Macroscopic Alignment of Self-Assembling Peptide Nanofibers.bioRxiv : the preprint server for biology · 2024
    Article
  18. Review
  19. Recent advances of 3D-printing in spine surgery.Surgical neurology international · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adam C FarsheedDepartment of Bioengineering, Rice University, Houston, TX, 77005, USA.ORCID https://orcid.org/0000-0003-0310-2144
Adam J ThomasDepartment of Chemistry, Rice University, Houston, TX, 77005, USA.
Brett H PogostinDepartment of Bioengineering, Rice University, Houston, TX, 77005, USA.ORCID https://orcid.org/0000-0002-1462-4442
Jeffrey D HartgerinkDepartment of Bioengineering, Rice University, Houston, TX, 77005, USA.ORCID https://orcid.org/0000-0002-3186-5395

Funding

Self-assembling Peptide Nanofiber Hydrogels for Nerve RegenerationR01DE021798 · NIDCR · RICE UNIVERSITY · PI HARTGERINK, JEFFREY DALE · 2012 to 2021
$3.7M
National Science FoundationNIDCR NIH HHS R01 DE021798NIH HHS R01 DE021798
6 · The paper itself

Abstract

3D printing has become one of the primary fabrication strategies used in biomedical research. Recent efforts have focused on the 3D printing of hydrogels to create structures that better replicate the mechanical properties of biological tissues. These pose a unique challenge, as soft materials are difficult to pattern in three dimensions with high fidelity. Currently, a small number of biologically derived polymers that form hydrogels are frequently reused for 3D printing applications. Thus, there exists a need for novel hydrogels with desirable biological properties that can be used as 3D printable inks. In this work, the printability of multidomain peptides (MDPs), a class of self-assembling peptides that form a nanofibrous hydrogel at low concentrations, is established. MDPs with different charge functionalities are optimized as distinct inks and are used to create complex 3D structures, including multi-MDP prints. Additionally, printed MDP constructs are used to demonstrate charge-dependent differences in cellular behavior in vitro. This work presents the first time that self-assembling peptides have been used to print layered structures with overhangs and internal porosity. Overall, MDPs are a promising new class of 3D printable inks that are uniquely peptide-based and rely solely on supramolecular mechanisms for assembly.

Indexed as

HydrogelsNanofibersPeptidesPorosityPrinting, Three-DimensionalTissue EngineeringHydrogelsPeptides3D printingbiomaterialshydrogelsself-assembling peptidessupramolecular chemistry

Identifiers

PMID36604310
PMCPMC10023392

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.