Evidence map›Paper›PMID 36604224›Full record

ArticleTrends in pharmacological sciences2023

Giving ERK a jERK from the endosome.

Evi Kostenis, Sergi Bravo, Jesus Gomeza

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in pharmacological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Evi KostenisDepartment of Molecular, Cellular, and Pharmacobiology, Institute of Pharmaceutical Biology, University of Bonn, Bonn, Germany. Electronic address: kostenis@uni-bonn.de.
Sergi BravoDepartment of Molecular, Cellular, and Pharmacobiology, Institute of Pharmaceutical Biology, University of Bonn, Bonn, Germany.
Jesus GomezaDepartment of Molecular, Cellular, and Pharmacobiology, Institute of Pharmaceutical Biology, University of Bonn, Bonn, Germany.
University of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endosomes, long considered as sorting stations for downregulation and recycling of cell surface G protein-coupled receptors (GPCRs), are now well-established sites of signal transduction. Recent work from the groups of Jin Zhang and Roger Sunahara features endosomes as signaling hubs and physical platforms for noncanonical activation of ERK by GPCRs.

Indexed as

EndosomesMAP Kinase Signaling SystemReceptors, G-Protein-CoupledCell MembraneHumansProtein TransportSignal TransductionReceptors, G-Protein-Coupled

Identifiers

PMID36604224
OpenAlexW4313459051

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.