Evidence map›Paper›PMID 36604172›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

A Novel and Functionally Diverse Class of Acetylcholine-Gated Ion Channels.

Iris Hardege, Julia Morud, Amy Courtney, William R Schafer

Open access · hybridAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Hierarchical behavior control by a single class of interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Neuronally produced betaine acts via a ligand-gated ion channel to control behavioral states.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Iris HardegeMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0001-6063-5954
Julia MorudMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Amy CourtneyMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
William R SchaferMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom wschafer@mrc-lmb.cam.ac.uk.
MRC Laboratory of Molecular Biology · GB

Funding

The neuropeptidergic connectome of Caenorhabitis elegantR01NS110391 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BEETS, ISABEL, HOBERT, OLIVER · 2018 to 2021
$2.0M
Medical Research Council MC-A023-5PB91NINDS NIH HHS R01 NS110391Wellcome Trust WT103784MA
6 · The paper itself

Abstract

Fast cholinergic neurotransmission is mediated by acetylcholine-gated ion channels; in particular, excitatory nicotinic acetylcholine receptors play well established roles in virtually all nervous systems. Acetylcholine-gated inhibitory channels have also been identified in some invertebrate phyla, yet their roles in the nervous system are less well understood. We report the existence of multiple new inhibitory ion channels with diverse ligand activation properties in

Indexed as

Ligand-Gated Ion ChannelsReceptors, NicotinicAcetylcholineAnimalsCaenorhabditis elegansCholineCholinergic AgentsLigandsAcetylcholineCholineCholinergic AgentsLigand-Gated Ion ChannelsLigandsReceptors, NicotinicacetylcholineC. eleganscholineion channeloctopaminetyramine

Identifiers

PMID36604172
PMCPMC9962794
OpenAlexW4313555720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.