ArticleThe Journal of infection2023
All Staphylococcus aureus bacteraemia-inducing strains can cause infective endocarditis: Results of GWAS and experimental animal studies.
Article in The Journal of infection, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Genomic comparison of Staphylococcus aureus isolates from patients with bacteraemia and infective endocarditis at public hospitals in Gauteng, South Africa.World journal of microbiology & biotechnology · 2026Article
- Genetic determinants of Staphylococcus aureus adhesion shape virulence trade-offs in bacteremia.Nature communications · 2026Article
- A chimeric, half-life extended lysin with a unique mode of action.Frontiers in microbiology · 2026Article
- Staphylococcus aureus agr-type vs genetic background: molecular signatures determining differential metabolism and virulence potential.PloS one · 2026Article
- Pathoadapative Genomic Determinants ofMicroorganisms · 2025Article
- Bacterial genome-wide association studies: exploring the genetic variation underlying bacterial phenotypes.Applied and environmental microbiology · 2025Review
- The endothelium at the interface between tissues andClinical microbiology reviews · 2025Review
- Integrating multi-wet laboratory diagnostics to study staphylococci in animals in Uganda.BMC microbiology · 2024Article
- Epidemiological and microbial trends of infective endocarditis in western Norway: a 7-year prospective observational study.BMC infectious diseases · 2024Observational
- Green Synthesis of Silver Nanoparticles with Extracts fromBiomolecules · 2024Article
- Perioperative care in infective endocarditis.Indian journal of thoracic and cardiovascular surgery · 2024Review
- RlmQ: a newly discovered rRNA modification enzyme bridging RNA modification and virulence traits inRNA (New York, N.Y.) · 2024Article
- Vegetation Formation inFrontiers in cellular and infection microbiology · 2022Article
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Authors and funding
21 authors at 15 institutions in 5 countries.
Funding
Abstract
objectivesWe aimed at determining whether specific S. aureus strains cause infective endocarditis (IE) in the course of Staphylococcus aureus bacteraemia (SAB).
methodsA genome-wide association study (GWAS) including 924 S. aureus genomes from IE (274) and non-IE (650) SAB patients from international cohorts was conducted, and a subset of strains was tested with two experimental animal models of IE, one investigating the early step of bacterial adhesion to inflamed mice valves, the second evaluating the local and systemic developmental process of IE on mechanically-damaged rabbit valves.
resultsThe genetic profile of S. aureus IE and non-IE SAB strains did not differ when considering single nucleotide polymorphisms, coding sequences, and k-mers analysed in GWAS. In the murine inflammation-induced IE model, no difference was observed between IE and non-IE SAB strains both in terms of adhesion to the cardiac valves and in the propensity to cause IE; in the mechanical IE-induced rabbit model, there was no difference between IE and non-IE SAB strains regarding the vegetation size and CFU.
conclusionAll strains of S. aureus isolated from SAB patients must be considered as capable of causing this common and lethal infection once they have accessed the bloodstream.
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