Evidence map›Paper›PMID 36603771›Full record

ArticleAntiviral research2023

A small molecule that targets the processivity factor of molluscum contagiosum virus has therapeutic potential.

Hancheng Guan, Manunya Nuth, Stuart N Isaacs, Yuhong Xiao, Richard W Scott, Michael H Parker, Eric D Strobel, John L Kulp, Thomas R Bailey, Allen B Reitz and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antiviral research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Hancheng GuanDepartment of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, USA.
Manunya NuthDepartment of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, USA.
Stuart N IsaacsPerelman School of Medicine, University of Pennsylvania, USA.
Yuhong XiaoPerelman School of Medicine, University of Pennsylvania, USA.
Richard W ScottFox Chase Chemical Diversity Center, USA.
Michael H ParkerFox Chase Chemical Diversity Center, USA.
Eric D StrobelFox Chase Chemical Diversity Center, USA.
John L KulpConifer Point Pharmaceuticals, Doylestown, PA, USA.
Thomas R BaileyTR Bailey Consulting LLC, Phoenixville, PA, USA.
Allen B ReitzFox Chase Chemical Diversity Center, USA.
Robert P RicciardiDepartment of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, USA; Abramson Cancer Center, School of Medicine, University of Pennsylvania, USA. Electronic address: ricciard@upenn.edu.
University of Pennsylvania · USFox Chase Chemical Diversity Center · US

Funding

Development of a Peptide-Drug Conjugate for Topically Treating the Viral Skin Disease Molluscum ContagiosumR41AI162385 · NIAID · FOX CHASE CHEMICAL DIVERSITY CENTER, INC · PI RICCIARDI, ROBERT PAUL · 2021 to 2022
$607k
NIAID NIH HHS R41 AI162385
6 · The paper itself

Abstract

Molluscum contagiosum (MC) is an infectious disease that occurs only in humans with a tropism that is narrowly restricted to the outermost epidermal layer of the skin. Molluscum contagiosum virus (MCV) is the causative agent of MC which produces skin lesions that can persist for months to several years. MCV is efficiently transmitted by direct physical contact or by indirect contact with fomites. MC is most prevalent in children and immune compromised patients. The failure to develop a drug that targets MCV replication has been hampered for decades by the inability to propagate MCV in cell culture. To address this dilemma, we recently engineered a surrogate poxvirus expressing the MCV processivity factor (mD4) as the drug target. The mD4 protein is essential for viral replication by keeping the viral polymerase tethered to the DNA template. In this study we have designed and synthesized a lead compound (7269) that is able to prevent mD4 dependent processive DNA synthesis in vitro (IC

Indexed as

Molluscum ContagiosumMolluscum contagiosum virusChildDNAHumansViral ProteinsDNAViral ProteinsAntiviralMechanism DNA synthesisMedical needMolluscum contagiosumProcessivity factorSkin disease

Identifiers

PMID36603771
PMCPMC10209390
OpenAlexW4313479678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.