Evidence map›Paper›PMID 36603046›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2023

Lung de-recruitment in the allergic asthma of obesity: evidence from an anatomically based inverse model.

Jason H T Bates, David A Kaminsky, Olivia J Garrow, Francesca K Martin, Ubong Peters, W Gabe Tharp, Anne E Dixon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jason H T BatesVermont Lung Center, University of Vermont Larner College of Medicine, Burlington, Vermont.ORCID 0000-0002-6062-6377
David A KaminskyVermont Lung Center, University of Vermont Larner College of Medicine, Burlington, Vermont.
Olivia J GarrowVermont Lung Center, University of Vermont Larner College of Medicine, Burlington, Vermont.
Francesca K MartinVermont Lung Center, University of Vermont Larner College of Medicine, Burlington, Vermont.
Ubong PetersGenentech Inc., Roche Group, South San Francisco, California.ORCID 0000-0002-2491-9519
W Gabe TharpDepartment of Anesthesiology, University of Vermont Larner College of Medicine, Burlington, Vermont.ORCID 0000-0003-4642-8750
Anne E DixonVermont Lung Center, University of Vermont Larner College of Medicine, Burlington, Vermont.
University of Vermont · USRoche (United States) · US

Funding

Mitochondrial Redox Perturbations in Obese Allergic AsthmaR01HL136917 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS, DIXON, ANNE E · 2018 to 2022
$3.6M
Non-Allergic Late-Onset Asthma of Obesity: Pathophysiology and TherapyR01HL130847 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BATES, JASON HT, DIXON, ANNE E · 2016 to 2019
$2.3M
NHLBI NIH HHS R01 HL130847NHLBI NIH HHS R01 HL136917
6 · The paper itself

Abstract

The increase in asthma associated with the obesity epidemic cannot simply be due to airway hyperresponsiveness from chronic lung compression because chronic lung compression is a feature of obesity in general. We therefore sought to investigate what other factors might be at play in the impaired lung function seen in obese individuals with asthma. We measured respiratory system impedance in four groups-Lean Control, Lean Allergic Asthma, Obese Control, and Obese Allergic Asthma-before and after administration of albuterol. Impedance measurements were fit with an anatomically based computational model of lung mechanics that represents the airway tree as a branching structure with a uniform degree of asymmetry and a fixed radius scaling ratio, γ, between branches of sequential order. The two model parameters that define the airway tree, γ and tracheal radius, varied only modestly between the four study groups, indicating relatively minor differences in airway caliber. In contrast, respiratory system elastance was 57, 34, 143, and 271 cmH

Indexed as

AsthmaAlbuterolHumansLungObesityRespiratory Function TestsAlbuterolairway caliberairway closurebronchodilationosillometryrespiratory system elastance

Identifiers

PMID36603046
PMCPMC9886348
OpenAlexW4313535126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.