Evidence map›Paper›PMID 36603028›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice.

Marina Boido, Iacopo Gesmundo, Anna Caretto, Francesca Pedrolli, Roberta Schellino, Sheila Leone, Renzhi Cai, Wei Sha, Ezio Ghigo, Andrew V Schally and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Growth hormone-releasing hormone and cancer.Reviews in endocrine & metabolic disorders · 2025
    Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Marina BoidoDepartment of Neuroscience "Rita Levi Montalcini", Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10043 Turin, Italy.ORCID 0000-0003-1211-1552
Iacopo GesmundoDivision of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0003-4901-4764
Anna CarettoDepartment of Neuroscience "Rita Levi Montalcini", Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10043 Turin, Italy.
Francesca PedrolliDivision of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0001-9404-7691
Roberta SchellinoDepartment of Neuroscience "Rita Levi Montalcini", Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10043 Turin, Italy.
Sheila LeoneDepartment of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.ORCID 0000-0003-1291-550X
Renzhi CaiEndocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, Miami, FL 33125.
Wei ShaEndocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, Miami, FL 33125.
Ezio GhigoDivision of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Andrew V SchallyEndocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, Miami, FL 33125.ORCID 0000-0003-1273-6747
Alessandro VercelliDepartment of Neuroscience "Rita Levi Montalcini", Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10043 Turin, Italy.ORCID 0000-0002-5909-2128
Riccarda GranataDivision of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0003-4164-7313
Neuroscience Institute · ITUniversity of Turin · ITSouth Florida Veterans Affairs Foundation for Research and Education · USUniversity of Chieti-Pescara · ITUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal muscular atrophy (SMA) is a severe autosomal recessive neuromuscular disease affecting children and young adults, caused by mutations of the survival motor neuron 1 gene (

Indexed as

Growth Hormone-Releasing HormoneMuscular Atrophy, SpinalAnimalsAtrophyDisease Models, AnimalMiceMotor NeuronsSpinal CordSurvival of Motor Neuron 1 ProteinGrowth Hormone-Releasing HormoneSurvival of Motor Neuron 1 Proteinalpha motor neuronsGHRH agonistsneuroinflammationneuromuscular junctionspinal muscular atrophy

Identifiers

PMID36603028
PMCPMC9926281
OpenAlexW4313545196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.