Evidence map›Paper›PMID 36602845›Full record

ArticleAmerican journal of respiratory and critical care medicine2023

Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants.

Anna L Peljto, Rachel Z Blumhagen, Avram D Walts, Jonathan Cardwell, Julia Powers, Tamera J Corte, Joanne L Dickinson, Ian Glaspole, Yuben P Moodley, Martina Koziar Vasakova and 105 more

Erratum issued Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06702228 (Precision Diagnosis and Care for Families With Pulmonary Fibrosis in Ireland [PRECISE-PF]), which is not on this map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
19.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06702228 recruitingnot on this map

Precision Diagnosis and Care for Families With Pulmonary Fibrosis in Ireland [PRECISE-PF]

TypeobservationalSponsorRoyal College of Surgeons, IrelandRan2021 to 2028Enrolled300ConditionsConnective Tissue Diseases, Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Familial Idiopathic Pulmonary FibrosisArmsSix minute walk test (6MWT), Computer-tomography of the thorax (CT Thorax), Quality of life questionnaires., Genetic Testing, Spirometry
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Common single nucleotide polymorphisms associated with idiopathic pulmonary fibrosis: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2024
    Pooled it
  4. Article
  5. Somatic mutation analysis of mucin genes and pathways in idiopathic pulmonary fibrosis.American journal of respiratory and critical care medicine · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Pharmacological mechanism of active components inFrontiers in pharmacology · 2026
    Article
  15. Article
  16. Review
  17. Genetic Familial Interstitial Lung Disease.Clinics in chest medicine · 2025
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

115 authors at 20 institutions in 22 countries.

Anna L PeljtoDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-8389-0736
Rachel Z BlumhagenDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Avram D WaltsNational Jewish Health, Denver, Colorado.
Jonathan CardwellDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Julia PowersDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Tamera J CorteRoyal Prince Alfred Hospital, University of Sydney, Sydney, Australia.
Joanne L DickinsonMenzies Institute of Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Ian GlaspoleAllergy, Asthma and Clinical Immunology Clinic, Alfred Health, Sydney, Australia.
Yuben P MoodleyDepartment of Respiratory Medicine, University of Western Australia, Perth, Australia.
Martina Koziar VasakovaDepartment of Respiratory Medicine, University Thomayer Hospital, Prague, Czech Republic.
Elisabeth BendstrupCenter for Rare Lung Diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.
Jesper R DavidsenSouth Danish Center for Interstitial Lung Diseases, Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.ORCID 0000-0003-4128-4014
Raphael BorieService de Pneumologie A and.ORCID 0000-0002-9906-0024
Bruno CrestaniService de Pneumologie A and.
Philippe DieudeService de Rhumatologie, Hopital Bichat, Paris, France.
Francesco BonellaCenter for Interstitial and Rare Lung Diseases, Ruhrlandklinik University Hospital, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0001-7579-9767
Ulrich CostabelCenter for Interstitial and Rare Lung Diseases, Ruhrlandklinik University Hospital, University of Duisburg-Essen, Essen, Germany.
Gunnar GudmundssonFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Seamas C DonnellyTrinity College Dublin, Dublin, Ireland.
Jim EganNational Lung Transplantation Centre, Mater Misericordiae University Hospital, Dublin, Ireland.
Michael T HenryDepartment of Respiratory Medicine, Cork University Hospital, Cork, Ireland.
Michael P KeaneSt. Vincent's University Hospital, University College Dublin, Dublin, Ireland.
Marcus P KennedyDepartment of Respiratory Medicine, Cork University Hospital, Cork, Ireland.
Cormac McCarthySt. Vincent's University Hospital, University College Dublin, Dublin, Ireland.
Aoife N McElroyTrinity College Dublin, Dublin, Ireland.
Joshua A OlaniyiTrinity College Dublin, Dublin, Ireland.
Katherine M A O'ReillyMater Misericordiae University Hospital, Dublin, Ireland.
Luca RicheldiFondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
Paolo M LeoneFondazione Policlinico A. Gemelli IRCCS, Rome, Italy.ORCID 0000-0002-7868-8410
Venerino PolettiDepartment of Diseases of the Thorax, G. B. Morgagni Hospital, Forlì, Italy.
Francesco PuppoDepartment of Internal Medicine, University of Genoa, Genoa, Italy.ORCID 0000-0002-5393-0071
Sara TomassettiDepartment of Clinical and Experimental Medicine, Interventional Pulmonology Unit, Careggi University Hospital, Florence, Italy.ORCID 0000-0002-4781-6539
Valentina LuzziInterventional Pulmonology Unit, Careggi University Hospital, Florence, Italy.
Nurdan KokturkFaculty of Medicine, Gazi University, Ankara, Turkey.
Nesrin MogulkocDepartment of Pulmonology, Ege University Hospital, Izmir, Turkey.
Christine A FiddlerRoyal Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom.
Nikhil HiraniUniversity of Edinburgh, Edinburgh, United Kingdom.
R Gisli JenkinsNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Toby M MaherNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0001-7192-9149
Philip L MolyneauxNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Helen ParfreyRoyal Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom.
Rebecca BraybrookeDivision of Respiratory Medicine, University of Nottingham, Nottingham, United Kingdom.
Timothy S BlackwellVanderbilt University Medical Center, Nashville, Tennessee.
Peter D JacksonDepartment of Pulmonary and Critical Care Medicine, Virginia Commonwealth University, Richmond, Virginia.ORCID 0000-0001-5108-9381
Steven D NathanInova Fairfax Hospital, Falls Church, Virginia.
Mary K PorteousHospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Kevin K BrownNational Jewish Health, Denver, Colorado.
Jason D ChristiePerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Harold R CollardDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California.
Oliver EickelbergDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0001-7170-0360
Elena E FosterDivision of Pulmonary, Critical Care, and Sleep Medicine, School of Medicine, University of California, Davis, Sacramento, California.
Kevin F GibsonDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Marilyn GlassbergDivision of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Arizona, Phoenix, Arizona.
Daniel J KassDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0001-6597-7830
Jonathan A KropskiVanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-8923-1344
David LedererRegeneron Pharmaceuticals, Inc., Tarrytown, New York.
Angela L LinderholmDepartment of Internal Medicine, University of California, Davis, Davis, California.
Jim LoydVanderbilt University Medical Center, Nashville, Tennessee.
Susan K MathaiBaylor University Medical Center, Dallas, Texas.
Sydney B MontesiDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Imre NothDepartment of Medicine.
Justin M OldhamDepartment of Medicine and.ORCID 0000-0003-4957-8869
Amy J PalmiscianoDivision of Pulmonary, Critical Care and Sleep Medicine, Alpert Medical School, Brown University, Providence, Rhode Island.
Cristina A ReichnerDivision of Pulmonary, Critical Care and Sleep Medicine, MedStar Georgetown University Hospital, Washington, DC.
Mauricio RojasDivision of Pulmonary, Critical Care, and Sleep Medicine, Ohio State University, Columbus, Ohio.
Jesse RomanDivision of Pulmonary, Allergy, and Critical Care, Thomas Jefferson University, Philadelphia, Pennsylvania.
Neil SchlugerColumbia University Medical Center, New York, New York.
Barry S SheaDivision of Pulmonary, Critical Care and Sleep Medicine, Alpert Medical School, Brown University, Providence, Rhode Island.
Jeffrey J SwigrisNational Jewish Health, Denver, Colorado.
Paul J WoltersDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California.
Yingze ZhangDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Cecilia M A PreleInstitute for Respiratory Health, University of Western Australia, Perth, Australia.
Juan I EnghelmayerBrown University, Providence, Rhode Island.
Maria OtaolaInstituto de Rehabilitación Psicofísica de Buenos Aires, Buenos Aires, Argentina.
Christopher J RyersonDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Mauricio SalinasDepartamento de Medicina, Universidad de Chile, Santiago, Chile.ORCID 0000-0001-7278-9088
Martina SterclovaCenter for Rare Lung Diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.
Tewodros H GebremariamCollege of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Marjukka MyllärniemiDepartment of Pulmonary Medicine, Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
Roberto G CarboneDepartment of Internal Medicine, University of Genoa, Genoa, Italy.
Haruhiko FurusawaDepartment of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0002-5569-1051
Masaki HiroseNational Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan.
Yoshikazu InoueNational Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan.ORCID 0000-0003-3994-874X
Yasunari MiyazakiDepartment of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0002-9073-9815
Ken OhtaNational Hospital Organization Tokyo National Hospital, Tokyo, Japan.
Shin OhtaDepartment of Medicine, Showa University, Tokyo, Japan.ORCID 0000-0001-8744-6096
Tsukasa OkamotoDepartment of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Dong Soon KimAsan Medical Center, University of Ulsan, Seoul, Republic of Korea.
Annie PardoFaculty of Sciences, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Moises SelmanInstituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Alvaro U ArandaCardiopulmonary Research Center, Alliance Pulmonary Group, Guaynabo, Puerto Rico.
Moo Suk ParkSeverance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0003-0820-7615
Jong Sun ParkSeoul National University Bundang Hospital, Seoul National University, Seongnam, Republic of Korea.
Jin Woo SongAsan Medical Center, University of Ulsan, Seoul, Republic of Korea.
Maria Molina-MolinaRespiratory Department and.
Lurdes Planas-CerezalesInterstitial Lung Disease Multidisciplinary Unit, University Hospital of Bellvitge, University of Barcelona, Barcelona, Spain.ORCID 0000-0001-7636-444X
Gunilla Westergren-ThorssonDepartment of Experimental Medical Science, Lung Biology Unit, Lund University, Lund, Sweden.
Albert V SmithDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan.
Ani W ManichaikulCenter for Public Health Genomics, and.
John S KimDepartment of Medicine.
Stephen S RichCenter for Public Health Genomics, and.
Elizabeth C OelsnerDepartment of Medicine and Department of Epidemiology, Columbia University Medical Center, New York, New York.
R Graham BarrDepartment of Medicine and Department of Epidemiology, Columbia University Medical Center, New York, New York.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California.
Josee DupuisDepartment of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts.
George O'ConnorPulmonary Center, School of Medicine, Boston University, Boston, Massachusetts.
Ramachandran S VasanBoston University and National Heart, Lung, and Blood Institute Framingham Heart Study, Boston, Massachusetts; and.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Marvin I SchwarzDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Mark P SteeleDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Joyce S LeeDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Ivana V YangDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Tasha E FingerlinNational Jewish Health, Denver, Colorado.
David A SchwartzDepartment of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0001-6743-8443
University of Colorado Anschutz Medical Campus · USNational Jewish Health · USUniversity of Pittsburgh · USColumbia University Irving Medical Center · USTokyo Medical and Dental University · JPTrinity College Dublin · IEVanderbilt University Medical Center · USAsan Medical Center · KRAzienda Ospedaliero-Universitaria Careggi · ITBoston University · USBrigham and Women's Hospital · USBrown University · USCork University Hospital · IEImperial College London · GBMater Misericordiae University Hospital · IENHO Kinki Chuo Chest Medical Center · JPOffice of Public Health Genomics · USPapworth Hospital NHS Foundation Trust · GBRuhrlandklinik · DEThe University of Western Australia · AU

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Mechanisms of Familial Pulmonary FibrosisP01HL092870 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLACKWELL, TIMOTHY S. · 2010 to 2020
$21.6M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
BLRD VA I01 BX002378BLRD VA I01 BX005295NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHGRI NIH HHS U54 HG003067NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201500014CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K23 HL130627NHLBI NIH HHS K23 HL138190NHLBI NIH HHS K23 HL150331NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS P01 HL092870NHLBI NIH HHS P01-HL0928701NHLBI NIH HHS P01 HL162607NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL145372NHLBI NIH HHS R01 HL146519NHLBI NIH HHS R01 HL149836NHLBI NIH HHS R01 HL158668NHLBI NIH HHS R21 HL129924NHLBI NIH HHS R21 HL153700NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL120393NHLBI NIH HHS UG3 HL151865NHLBI NIH HHS UG3-HL151865NHLBI NIH HHS UH2/3-HL123442NHLBI NIH HHS UH2 HL123442NHLBI NIH HHS UH3 HL123442NHLBI NIH HHS UH3 HL151865NHLBI NIH HHS X01-HL134585NIDDK NIH HHS P30 DK063491NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Idiopathic Pulmonary FibrosisExomeHumansWhole Genome Sequencinggenetic association studiesinterstitial lung diseasetelomeraseTOPMedwhole-genome sequencing

Identifiers

PMID36602845
PMCPMC10161752
OpenAlexW4313544423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.