ArticleBiomechanics and modeling in mechanobiology2023
Effects of geometric individualisation of a human spine model on load sharing: neuro-musculoskeletal simulation reveals significant differences in ligament and muscle contribution.
Article in Biomechanics and modeling in mechanobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Advances in Musculoskeletal Modeling of the Thoraco-Lumbar Spine: A Comprehensive Systematic Review.Annals of biomedical engineering · 2025Pooled it
- A stiffness-dependent method to estimate spine kinematics and loading reveals the impact of nonlinear mechanics during lifting tasks.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Segment-specific prediction of vertebral collapse severity in osteoporotic fractures.Frontiers in endocrinology · 2026Article
- A Muscle-Driven Spine Model for Predictive Simulations in the Design of Spinal Implants and Lumbar Orthoses.Bioengineering (Basel, Switzerland) · 2025Article
- Elastic textile-based wearable modulation of musculoskeletal load: A comprehensive review of passive exosuits and resistance clothing.Wearable technologies · 2025Review
- Article
- Identification of a lumped-parameter model of the intervertebral joint from experimental data.Frontiers in bioengineering and biotechnology · 2024Article
- Musculoskeletal spine modeling in large patient cohorts: how morphological individualization affects lumbar load estimation.Frontiers in bioengineering and biotechnology · 2024Article
- Effect of neglecting passive spinal structures: a quantitative investigation using the forward-dynamics and inverse-dynamics musculoskeletal approach.Frontiers in physiology · 2023Article
- Invasiveness of decompression surgery affects modeled lumbar spine kinetics in patients with degenerative spondylolisthesis.Frontiers in bioengineering and biotechnology · 2023Article
- Muscle-driven forward dynamic active hybrid model of the lumbosacral spine: combined FEM and multibody simulation.Frontiers in bioengineering and biotechnology · 2023Article
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
In spine research, two possibilities to generate models exist: generic (population-based) models representing the average human and subject-specific representations of individuals. Despite the increasing interest in subject specificity, individualisation of spine models remains challenging. Neuro-musculoskeletal (NMS) models enable the analysis and prediction of dynamic motions by incorporating active muscles attaching to bones that are connected using articulating joints under the assumption of rigid body dynamics. In this study, we used forward-dynamic simulations to compare a generic NMS multibody model of the thoracolumbar spine including fully articulated vertebrae, detailed musculature, passive ligaments and linear intervertebral disc (IVD) models with an individualised model to assess the contribution of individual biological structures. Individualisation was achieved by integrating skeletal geometry from computed tomography and custom-selected muscle and ligament paths. Both models underwent a gravitational settling process and a forward flexion-to-extension movement. The model-specific load distribution in an equilibrated upright position and local stiffness in the L4/5 functional spinal unit (FSU) is compared. Load sharing between occurring internal forces generated by individual biological structures and their contribution to the FSU stiffness was computed. The main finding of our simulations is an apparent shift in load sharing with individualisation from an equally distributed element contribution of IVD, ligaments and muscles in the generic spine model to a predominant muscle contribution in the individualised model depending on the analysed spine level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.