Evidence map›Paper›PMID 36602585›Full record

ArticleHistochemistry and cell biology2023

PLAC8 contributes to the malignant behaviors of cervical cancer cells by activating the SOX4-mediated AKT pathway.

Boya Deng, Siyang Zhang, Yingying Zhou, Ying Zhu, Jing Fei, Ailin Li

Abstract read
PubMed Publisher
In one paragraph

Article in Histochemistry and cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Boya DengDepartment of Gynecology, The Second Affiliated Hospital of Zhejiang University, Shangcheng District, 88 Jiefang Road, Hangzhou, Zhejiang, China. boyadeng@zju.edu.cn.
Siyang ZhangScience Experimental Center of China Medical University, Shenyang, Liaoning, China.
Yingying ZhouDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Ying ZhuDepartment of Gynecology, The Second Affiliated Hospital of Zhejiang University, Shangcheng District, 88 Jiefang Road, Hangzhou, Zhejiang, China.
Jing FeiDepartment of Gynecology, The Second Affiliated Hospital of Zhejiang University, Shangcheng District, 88 Jiefang Road, Hangzhou, Zhejiang, China.
Ailin LiDepartment of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
China Medical University · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

National Natural Science Foundation of China 82103491
6 · The paper itself

Abstract

Cervical cancer (CC) is the primary cancer-related cause of morbidity and mortality in women. Previous studies have shown that placenta-specific 8 (PLAC8) has different functions in multiple malignancies. This study aimed to explore the function and regulatory mechanism of PLAC8 in CC. Bioinformatics and immunohistochemical analyses demonstrated that PLAC8 was significantly upregulated in CC tissues compared with normal tissues. Gain/loss-of-function experiments showed that siRNA-mediated knockdown of PLAC8 suppressed cell migration and invasion, while PLAC8 overexpression promoted cell motility. Moreover, PLAC8 was revealed to affect the epithelial-mesenchymal transition (EMT) process by upregulating epithelial (E)-cadherin and decreasing the expression of mesenchymal markers of EMT, including vimentin, zinc finger E-box binding homeobox 1 (ZEB1), neural (N)-cadherin, matrix metalloproteinase-9 (MMP-9), and MMP-2 in PLAC8-silenced cells. PLAC8 activated the AKT pathway, as proven by the downregulation of p-AKT

Indexed as

Proto-Oncogene Proteins c-aktUterine Cervical NeoplasmsCadherinsCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansProteinsSOXC Transcription FactorsZinc Finger E-box-Binding Homeobox 1CadherinsPLAC8 protein, humanProteinsProto-Oncogene Proteins c-aktSOX4 protein, humanSOXC Transcription FactorsZinc Finger E-box-Binding Homeobox 1AKT pathwayCervical cancerEMTPLAC8SOX4

Identifiers

PMID36602585
OpenAlexW4313545303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.