Trial reportEuropean journal of haematology2023
Time to pain relief: A randomized controlled trial in the emergency department during vaso-occlusive episodes in sickle cell disease.
Trial report in European journal of haematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Impact of Individualized Versus Weight-Based Pain Protocols on Patient Satisfaction for Patients With Sickle Cell Disease Experiencing a Vaso-Occlusive Episode.Journal of emergency nursing · 2025Trial
- Impact of an individualized pain plan to treat sickle cell disease vaso-occlusive episodes in the emergency department.Blood advances · 2024Trial
- Illness Identity in Symptomatic Adults with Sickle Cell Disease: Preliminary Findings and Considerations.Journal of clinical psychology in medical settings · 2026Article
- Use of Emergency Severity Index 2 reduces time to first analgesia in sickle cell disease vaso-occlusive crisis.Blood advances · 2025Article
- Comparative results of percutaneous and open surgery for trigger fingers: a propensity score analysis.Frontiers in surgery · 2025Article
- What interval of daily pain assessment is required to reliably diagnose chronic pain in SCD? The Pain in Sickle Cell Epidemiology Study.Journal of sickle cell disease · 2024Article
- A comparison of the effect of patient-specific versus weight-based protocols to treat vaso-occlusive episodes in the emergency department.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveCompare time to pain relief (minimum of a 13 mm and 30% reduction) during an Emergency Department (ED) visit among patients with sickle cell disease (SCD) experiencing severe pain associated with a vaso-occlusive episode who were randomized to receive either an individualized or weight-based pain protocol.
methodsA randomized controlled trial in two EDs. Adults with sickle cell disease. Research staff recorded pain scores every 30 min during an ED visit (up to 6 h in the ED) using a 0-100 mm visual analogue scale. Analysis included 122 visits, representing 49 patients (individualized: 61 visits, 25 patients; standard: 61 visits, 24 patients).
resultsPain reduction across 6-h was greater for the individualized compared to the standard protocol (protocol-by-time: p = .02; 6-h adjusted pain score comparison: Individualized: M = 29.2, SD = 38.8, standard: M = 45.3, SD = 35.6; p = .03, Cohen d = 0.43). Hazards models indicated a greater probability of 13 mm (HR = 1.54, 95% CI = 1.05, 2.27, p = .03) and 30% (HR = 1.71, 95% CI = 1.11, 2.63, p = .01) reduction in the individualized relative to the standard protocol.
conclusionsPatients who received treatment with an individualized protocol experienced a more rapid reduction in pain, including a 13 mm and 30% reduction in pain scores when compared to those that received weight-based dosing.
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