Evidence map›Paper›PMID 36602381›Full record

ArticleInfection and immunity2023

The Protective Role of Interleukin 17A in Acinetobacter baumannii Pneumonia Is Associated with Candida albicans in the Airway.

Jiaxin Tang, Jiamin Li, Jinqing Pan, Xiaoyuan Shen, Xiangsheng Ye, Jiamin Zhou, Ni Wang, Liang Xie, Beth Burgwyn Fuchs, Michail S Lionakis and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. IL-17: Balancing Protective Immunity and Pathogenesis.Journal of immunology research · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Jiaxin TangDepartment of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0002-2561-8451
Jiamin LiDepartment of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jinqing PanDepartment of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiaoyuan ShenDepartment of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiangsheng YeDepartment of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jiamin ZhouDepartment of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ni WangDepartment of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Liang XieDepartment of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Beth Burgwyn FuchsDepartment of Medicine, Division of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Michail S LionakisFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0003-4994-9500
Eleftherios MylonakisDepartment of Medicine, Division of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.ORCID 0000-0002-4624-0777
Xiaojiang TanDepartment of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0001-6937-7699
Nanfang Hospital · CNBrown University · USNational Institutes of Health · US

Funding

Immunopathogenesis of Fungal InfectionsZIAAI001175 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LIONAKIS, MICHAIL · 2012 to 2025
$23.9M
Intramural NIH HHS ZIA AI001175
6 · The paper itself

Abstract

Recent studies have found that the coexistence of fungi and bacteria in the airway may increase the risk of infection, contribute to the development of pneumonia, and increase the severity of disease. Interleukin 17A (IL-17A) plays important roles in host resistance to bacterial and fungal infections. The objective of this study was to determine the effects of IL-17A on Acinetobacter baumannii-infected rats with a previous Candida albicans airway inoculation. The incidence of A. baumannii pneumonia was higher in rats with C. albicans in the airway than in noninoculated rats, and it decreased when amphotericin B was used to clear C. albicans, which influenced IL-17A levels. IL-17A had a protective effect in A. baumannii pneumonia associated with C. albicans in the airway. Compared with A. baumannii-infected rats with C. albicans in the airway that did not receive IL-17A, recombinant IL-17A (rIL-17A) supplementation decreased the incidence of A. baumannii pneumonia (10/15 versus 5/17;

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsPneumoniaPneumonia, BacterialAnimalsBacteriaCandida albicansInterleukin-17LungNeutrophilsRatsInterleukin-17Acinetobacter baumanniiapoptosisCandida albicansinterleukin 17Aneutrophils

Identifiers

PMID36602381
PMCPMC9872622
OpenAlexW4313545022

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.