Evidence map›Paper›PMID 36602305›Full record

ArticlemBio2023

Emergence of an Auxin Sensing Domain in Plant-Associated Bacteria.

José A Gavira, Miriam Rico-Jiménez, Álvaro Ortega, Natalia V Petukhova, Dmitrii S Bug, Albert Castellví, Yuri B Porozov, Igor B Zhulin, Tino Krell, Miguel A Matilla

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
6.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Indole-3-acetic acid (IAA) protectsApplied and environmental microbiology · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

José A GaviraLaboratory of Crystallographic Studies, IACT (CSIC-UGR), Armilla, Spain.ORCID 0000-0002-7386-6484
Miriam Rico-JiménezDepartment of Biotechnology and Environmental Protection, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain.
Álvaro OrtegaDepartment of Biochemistry and Molecular Biology B and Immunology, Faculty of Chemistry, University of Murcia, Regional Campus of International Excellence Campus Mare Nostrum, Murcia, Spain.ORCID 0000-0001-8202-293X
Natalia V PetukhovaBioinformatics Research Center, Pavlov First Saint Petersburg Medical State University, St. Petersburg, Russia.
Dmitrii S BugDepartment of Biochemistry and Molecular Biology B and Immunology, Faculty of Chemistry, University of Murcia, Regional Campus of International Excellence Campus Mare Nostrum, Murcia, Spain.
Albert CastellvíMolecular Biology Institute of Barcelona, CSIC, Barcelona, Spain.
Yuri B PorozovThe Center of Bio- and Chemoinformatics, I. M. Sechenov First Moscow State Medical University, Moscow, Russia.
Igor B ZhulinDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-6708-5323
Tino KrellDepartment of Biotechnology and Environmental Protection, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain.ORCID 0000-0002-9040-3166
Miguel A MatillaDepartment of Biotechnology and Environmental Protection, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain.ORCID 0000-0002-8468-9604
Consejo Superior de Investigaciones Científicas · ESUniversidad de Murcia · ESFirst Pavlov State Medical University of St. Petersburg · RUInstitut de Biologia Molecular de Barcelona · ESSechenov University · RUThe Ohio State University · US

Funding

Computational Genomics of Signal TransductionR35GM131760 · NIGMS · OHIO STATE UNIVERSITY · PI Igor B. Jouline · 2019 to 2026
$3.2M
NIGMS NIH HHS R35 GM131760
6 · The paper itself

Abstract

Bacteria have evolved a sophisticated array of signal transduction systems that allow them to adapt their physiology and metabolism to changing environmental conditions. Typically, these systems recognize signals through dedicated ligand binding domains (LBDs) to ultimately trigger a diversity of physiological responses. Nonetheless, an increasing number of reports reveal that signal transduction receptors also bind antagonists to inhibit responses mediated by agonists. The mechanisms by which antagonists block the downstream signaling cascade remain largely unknown. To advance our knowledge in this field, we used the LysR-type transcriptional regulator AdmX as a model. AdmX activates the expression of an antibiotic biosynthetic cluster in the rhizobacterium Serratia plymuthica. AdmX specifically recognizes the auxin phytohormone indole-3-acetic acid (IAA) and its biosynthetic intermediate indole-3-pyruvic acid (IPA) as signals. However, only IAA, but not IPA, was shown to regulate antibiotic production in

Indexed as

Indoleacetic AcidsPlant Growth RegulatorsAnti-Bacterial AgentsBacteriaPhylogenyPlantsAnti-Bacterial AgentsIndoleacetic AcidsPlant Growth Regulatorsantagonistantibioticauxinindole-3-acetic acidligandsLysRprotein evolutionsensor domainsignal sensingsignal transductionstructural biologytranscriptional regulator

Identifiers

PMID36602305
PMCPMC9973260
OpenAlexW4313546541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.