ArticleMovement disorders : official journal of the Movement Disorder Society2023
Clinical Diagnostic Accuracy of Parkinson's Disease: Where Do We Stand?
Article in Movement disorders : official journal of the Movement Disorder Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Utility of Olfactory Testing to Discriminate Parkinson's Disease From Diagnostic Mimics: A Systematic Review and Meta-Analysis.European journal of neurology · 2026Pooled it
- Diagnostic performance of PET-based artificial intelligence for differentiating Parkinson's disease from normal controls or atypical parkinsonism: a systematic review and meta-analysis.Journal of neurology · 2025Pooled it
- A curriculum-guided unified framework for robust unsupervised domain adaptation on multi-cohort Parkinson's disease diagnosis.Quantitative imaging in medicine and surgery · 2026Article
- Diagnostic, Prognostic Value, and Pathological Associations of Levodopa Responsiveness in Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy.Annals of neurology · 2026Article
- Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism.Annals of neurology · 2026Article
- Physical frailty, depressive symptoms, and cognitive decline before and after Parkinson's disease diagnosis: a population-based prospective study of the SHARE and ELSA cohorts.NPJ Parkinson's disease · 2026Article
- Iron accumulation in the substantia nigra is linked to functional network connectivity alterations in early-stage Parkinson's Disease: an exploratory study.NPJ Parkinson's disease · 2026Article
- Computer Vision Analysis for Objective Motor Assessment in Parkinson's Disease: A Retrospective Study.Movement disorders clinical practice · 2026Article
- Prebiotic intervention changes host and microbe proteomes in plasma extracellular vesicles of Parkinson's disease.Scientific reports · 2026Article
- Clinical correlates of a negative cerebrospinal fluid α-synuclein seed amplification assay result in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Epidemiological principles behind worldwide growth of Parkinson disease - a bathtub analogy.Nature reviews. Neurology · 2026Article
- AI-Enabled Flexible Sensing Ecosystems for Parkinson's Disease: Advancing Digital Biomarkers and Closed-Loop Interventions.Sensors (Basel, Switzerland) · 2026Review
- Hair metal dysregulation in Parkinson's disease: Implications for diagnosis and gut-brain axis involvement.iScience · 2026Article
- Towards biomarker-based diagnosis of Parkinson disease.Nature reviews. Neurology · 2026Review
- α-Synuclein in Lewy Body Diseases: Progress, Remaining Challenges and Future Perspectives.Expert reviews in molecular medicine · 2026Review
- CDS-PD: a novel clinical decision support platform for Parkinson's disease.Scientific reports · 2026Article
- Prompting and Fine-Tuning Large Language Models for Parkinson Disease Diagnosis: Comparative Evaluation Study Using the PPMI Structured Dataset.JMIR medical informatics · 2026Article
- White matter alterations in tremor-dominant and postural instability and gait disturbance subtypes of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Absence of STN Neuronal Activity during MER in DBS Surgery: Diagnostic and Clinical Implications.Stereotactic and functional neurosurgery · 2026Article
- Nutrition, functional status, polypharmacy, and digestive disturbances in institutionalized patients with dementia: insights from comprehensive screening at admission.Frontiers in nutrition · 2026Article
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Abstract
backgroundClinical diagnostic accuracy of Parkinson's disease (PD) remains suboptimal. Changes in disease concept may have improved clinical diagnostic accuracy in the past decade. However, current clinical diagnostic criteria have not been validated against neuropathological confirmation.
objectivesThis study aims to provide up-to-date clinical diagnostic accuracy data and validate current clinical diagnostic criteria for PD against neuropathology.
methodsA retrospective review of medical records of consecutive patients with parkinsonism from the Queen Square Brain Bank was performed between 2009 and 2019. Clinical diagnosis was documented at early (within 5 years of motor symptom onset) and final stages and categorized by movement disorder experts or regular clinicians. Movement Disorder Society Parkinson's disease (MDS-PD) diagnostic criteria were retrospectively applied. Diagnostic accuracy parameters (sensitivity, specificity, positive/negative predictive value, and accuracy) were calculated using neuropathological diagnosis as the gold standard.
resultsA total of 267 patients (141 PD and 126 non-PD parkinsonism) were included. Clinical diagnostic accuracy was 97.2% for experts, 92.5% for the MDS clinically probable PD criteria, and 90.3% for clinicians. Similar figures were obtained when applied at an early stage (91.5%, 89.5%, and 84.2% diagnostic accuracy, respectively). MDS clinically established early PD criteria demonstrated very high specificity (98.4%) at early stages.
conclusionsOur results showed an important improvement in PD clinical diagnostic accuracy in clinical practice over the past decade, more marked at early stages of the disease. MDS-PD diagnostic criteria is a valid tool in clinical practice and research for the identification of PD patients showing excellent sensitivity and specificity, although movement disorder experts' diagnosis remains the gold standard PD diagnosis during life. © 2023 International Parkinson and Movement Disorder Society.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.