Evidence map›Paper›PMID 36601665›Full record

ArticleClinical genetics2023

DKK1 is a strong candidate for mesiodens and taurodontism.

Piranit Kantaputra, Peeranat Jatooratthawichot, Naomi Kottege, Robert P Anthonappa, Massupa Kaewgahya, Sissades Tongsima, Chumpol Ngamphiw, James R Ketudat Cairns, Danilo Predes, Xi He

Open access · bronzeAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Heterozygous Variants inDiagnostics (Basel, Switzerland) · 2023
    Article
  4. Article
  5. Rare Genetic Variants in HumanInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Piranit KantaputraCenter of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.ORCID 0000-0001-9841-0881
Peeranat JatooratthawichotSchool of Chemistry, Institute of Science, and Center for Biomolecular Structure, Function and Application, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Naomi KottegeDepartment of Pediatric Dentistry, University of Western Australia Dental School, Nedlands, Western Australia, Australia.
Robert P AnthonappaDepartment of Pediatric Dentistry, University of Western Australia Dental School, Nedlands, Western Australia, Australia.
Massupa KaewgahyaCenter of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
Sissades TongsimaNational Biobank of Thailand, National Science and Technology Development Agency,Thailand Science Park, Pathum Thani, Thailand.
Chumpol NgamphiwNational Biobank of Thailand, National Science and Technology Development Agency,Thailand Science Park, Pathum Thani, Thailand.
James R Ketudat CairnsSchool of Chemistry, Institute of Science, and Center for Biomolecular Structure, Function and Application, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Danilo PredesF. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-1864-0324
Xi HeF. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-8093-7981
Boston Children's Hospital · USChiang Mai University · THNational Science and Technology Development Agency · THSuranaree University of Technology · THThe University of Western Australia · AU

Funding

SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
Wnt Signaling and Vertebrate embryogenesisR35GM134953 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI HE, XI · 2020 to 2024
$3.8M
NICHD NIH HHS P30 HD018655NIGMS NIH HHS R35 GM134953
6 · The paper itself

Abstract

A mutation in DKK1 gene leads to inhibitory DKK1 function, over-activation of WNT/β-catenin signaling, disruptive development of dental epithelium, and subsequent mesiodens formation.

Indexed as

Tooth Abnormalitiesbeta CateninDental Pulp CavityHumansIntercellular Signaling Peptides and ProteinsWnt Signaling Pathwaybeta CateninDKK1 protein, humanIntercellular Signaling Peptides and Proteinsmesiodenssupernumerary toothtaurodontismWNT signaling

Identifiers

PMID36601665
PMCPMC10159873
OpenAlexW4313544934

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.