Evidence map›Paper›PMID 36601628›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2022

Renal Function, Adherence and Quality of Life Improvement After Conversion From Immediate to Prolonged-Release Tacrolimus in Liver Transplantation: Prospective Ten-Year Follow-Up Study.

Luca Toti, Tommaso Maria Manzia, Francesca Blasi, Ilaria Lenci, Leonardo Baiocchi, Nicola Toschi, Giuseppe Tisone

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Observational
  3. Early Conversion to Once-Daily MeltDoseJournal of clinical medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Luca TotiHPB and Transplant Unit, Department of Surgery, University of Rome Tor Vergata, Rome, Italy.
Tommaso Maria ManziaHPB and Transplant Unit, Department of Surgery, University of Rome Tor Vergata, Rome, Italy.
Francesca BlasiHPB and Transplant Unit, Department of Surgery, University of Rome Tor Vergata, Rome, Italy.
Ilaria LenciHepatology and Liver Transplant Unit, University of Rome Tor Vergata, Rome, Italy.
Leonardo BaiocchiHepatology and Liver Transplant Unit, University of Rome Tor Vergata, Rome, Italy.
Nicola ToschiDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Roma, Italy.
Giuseppe TisoneHPB and Transplant Unit, Department of Surgery, University of Rome Tor Vergata, Rome, Italy.
European Society for Organ Transplantation · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunosuppression non-adherence is a major cause of graft failure after liver transplantation. The aim of this study was to evaluate practice surrounding conversion from immediate-release to prolonged-release Tacrolimus formulation and to assess patient adherence and quality of life (QoL). One hundred and seven adult liver transplant recipients, receiving immediate-release Tacrolimus for a minimum of 6 months, were converted to prolonged-release formulation, based on a dose ratio of one (1:1). The median follow-up was 120 [IQR, 120-123] months. Tacrolimus dosage and blood level, liver and renal function, lipid and glucose profiles were recorded. In addition, questionnaires were submitted to evaluate adherence and QoL following conversion. No rejection was recorded. The median serum Tacrolimus blood level decreased over 1 month (5.80, [IQR, 2.0-10.8] vs. 3.8 [IQR, 1.4-8.7];

Indexed as

Liver TransplantationTacrolimusAdultFollow-Up StudiesGraft RejectionHumansImmunosuppressive AgentsMedication AdherenceProspective StudiesQuality of LifeImmunosuppressive AgentsTacrolimusadherenceimmunosuppressionliver transplantationquality of lifeTacrolimus

Identifiers

PMID36601628
PMCPMC9806113
OpenAlexW4313388515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.