Evidence map›Paper›PMID 36601554›Full record

ArticleOpen forum infectious diseases2022

The US Department of Veterans Affairs Science and Health Initiative to Combat Infectious and Emerging Life-Threatening Diseases (VA SHIELD): A Biorepository Addressing National Health Threats.

John B Harley, Saiju Pyarajan, Elizabeth S Partan, Lauren Epstein, Jason A Wertheim, Abhinav Diwan, Christopher W Woods, Victoria Davey, Sharlene Blair, Dennis H Clark and 31 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Nationwide Genomic Surveillance and Response to COVID-19: The VA SeqFORCE and SeqCURE Consortiums.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2023
    Article
  4. VA SHIELD: A Biorepository for Veterans and the Nation.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2023
    Article
  5. VA Big Data Science: A Model for Improved National Pandemic Response Present and Future.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

John B HarleyResearch Services, US Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA.
Saiju PyarajanCenter for Data and Computational Sciences, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9047-3762
Elizabeth S PartanCenter for Data and Computational Sciences, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-3995-6742
Lauren EpsteinInfectious Diseases, US Department of Veterans Affairs Medical Center, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-1175-1112
Jason A WertheimResearch & Development, Southern Arizona Veterans Affairs Healthcare System, US Department of Veterans Affairs, Tucson, Arizona, USA.ORCID https://orcid.org/0000-0001-5680-1067
Abhinav DiwanCardiology, Veterans Affairs Saint Louis Healthcare System, US Department of Veterans Affairs, Saint Louis, Missouri, USA.ORCID https://orcid.org/0000-0001-7554-4772
Christopher W WoodsMedicine, US Department of Veterans Affairs Medical Center, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0001-7240-2453
Victoria DaveyOffice of Research and Development, US Department of Veterans Affairs, Washington, District of Columbia, USA.ORCID https://orcid.org/0000-0001-7402-6607
Sharlene BlairResearch Services, US Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0001-6289-4351
Dennis H ClarkResearch Services, US Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0002-5786-3216
Kenneth M KaufmanResearch Services, US Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0001-8195-1876
Shagufta KhanResearch Services, US Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA.
Iouri ChepelevResearch Services, US Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0002-2121-8805
Alexander DevinePrometheus Federal Services, Titan Alpha, Washington, District of Columbia, USA.ORCID https://orcid.org/0000-0002-9453-7348
Perry CameronCustomer Value Partners, Titan Alpha, Washington, District of Columbia, USA.ORCID https://orcid.org/0000-0002-9941-0661
Monica F McCannOffice of Research and Development, Chesapeake Medical Communications, Contractor for the US Department of Veterans Affairs, Washington, District of Columbia, USA.ORCID https://orcid.org/0000-0002-8092-1939
Mary Cloud B AmmonsResearch, US Department of Veterans Affairs Medical Center, Boise, Idaho, USA.ORCID https://orcid.org/0000-0002-9717-0844
Devin D BolzResearch, US Department of Veterans Affairs Medical Center, Boise, Idaho, USA.ORCID https://orcid.org/0000-0002-8658-1621
Jane K BattlesOffice of Research and Development, US Department of Veterans Affairs, Washington, District of Columbia, USA.ORCID https://orcid.org/0000-0002-2610-7063
Jeffrey L CurtisMedicine Service, Veteran Affairs Ann Arbor Healthcare System, US Department of Veterans Affairs, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0001-5191-4847
Mark HolodniyPublic Health Surveillance, Veterans Affairs Palo Alto Healthcare System, US Department of Veterans Affairs, Palo Alto, California, USA.ORCID https://orcid.org/0000-0002-6655-7982
Vincent C MarconiInfectious Diseases, US Department of Veterans Affairs Medical Center, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-8409-4689
Charles D SearlesInfectious Diseases, US Department of Veterans Affairs Medical Center, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-9469-0564
David O BeenhouwerMedicine, Veterans Affairs Greater Los Angeles Healthcare System, US Department of Veterans Affairs, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-9254-167X
Sheldon T BrownInfectious Diseases, James J. Peters Veterans Affairs Medical Center, US Department of Veterans Affairs, Bronx, New York, USA.ORCID https://orcid.org/0000-0002-4563-4854
Jonathan P MoormanInfectious Diseases, James H. Quillen Veterans Affairs Medical Center, US Department of Veterans Affairs, Mountain Home, Tennessee, USA.ORCID https://orcid.org/0000-0002-6102-6541
Zhi Q YaoInfectious Diseases, James H. Quillen Veterans Affairs Medical Center, US Department of Veterans Affairs, Mountain Home, Tennessee, USA.
Maria C Rodriguez-BarradasInfectious Diseases Section, Michael E. DeBakey Veterans Affairs Medical Center, US Department of Veterans Affairs, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-2446-2667
Shyam MohapatraMedicine, James A. Haley Veterans Hospital, US Department of Veterans Affairs, Tampa, Florida, USA.ORCID https://orcid.org/0000-0001-5838-0681
Osmara Y Molina De RodriguezResearch & Development, Southern Arizona Veterans Affairs Healthcare System, US Department of Veterans Affairs, Tucson, Arizona, USA.ORCID https://orcid.org/0000-0001-7695-7843
Emerson B PadiernosResearch, US Department of Veterans Affairs Medical Center, Boise, Idaho, USA.ORCID https://orcid.org/0000-0002-8472-174X
Eric R McIndooResearch, US Department of Veterans Affairs Medical Center, Boise, Idaho, USA.ORCID https://orcid.org/0000-0002-1306-3639
Emily PriceResearch, US Department of Veterans Affairs Medical Center, Boise, Idaho, USA.ORCID https://orcid.org/0000-0002-4147-7679
Hailey M BurgoyneResearch, US Department of Veterans Affairs Medical Center, Boise, Idaho, USA.ORCID https://orcid.org/0000-0002-1953-8156
Ian RobeyResearch & Development, Southern Arizona Veterans Affairs Healthcare System, US Department of Veterans Affairs, Tucson, Arizona, USA.ORCID https://orcid.org/0000-0001-8817-8476
Dawn C SchwenkeResearch & Development, Southern Arizona Veterans Affairs Healthcare System, US Department of Veterans Affairs, Tucson, Arizona, USA.ORCID https://orcid.org/0000-0003-0920-8441
Carey L ShiveMedicine, Veterans Affairs Northeast Ohio Healthcare System, US Department of Veterans Affairs, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-6908-1246
Ronald M PrzygodzkiOffice of Research and Development, US Department of Veterans Affairs, Washington, District of Columbia, USA.ORCID https://orcid.org/0000-0002-1238-262X
Rachel B RamoniOffice of Research and Development, US Department of Veterans Affairs, Washington, District of Columbia, USA.ORCID https://orcid.org/0000-0002-1459-9638
Holly K KrullOffice of Research and Development, US Department of Veterans Affairs, Washington, District of Columbia, USA.ORCID https://orcid.org/0000-0001-8856-7180
Robert A BonomoMedicine, Veterans Affairs Northeast Ohio Healthcare System, US Department of Veterans Affairs, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-3299-894X

Funding

COVID-19: Characterizing trained immune responses to COVID-19I01BX005428 · VA · JAMES H QUILLEN VA MEDICAL CENTER · PI MOORMAN, JONATHAN P · 2021 to 2022
–
BLRD VA I01 BX005428
6 · The paper itself

Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has demonstrated the need to share data and biospecimens broadly to optimize clinical outcomes for US military Veterans. Methods: In response, the Veterans Health Administration established VA SHIELD (Science and Health Initiative to Combat Infectious and Emerging Life-threatening Diseases), a comprehensive biorepository of specimens and clinical data from affected Veterans to advance research and public health surveillance and to improve diagnostic and therapeutic capabilities. Results: VA SHIELD now comprises 12 sites collecting de-identified biospecimens from US Veterans affected by SARS-CoV-2. In addition, 2 biorepository sites, a data processing center, and a coordinating center have been established under the direction of the Veterans Affairs Office of Research and Development. Phase 1 of VA SHIELD comprises 34 157 samples. Of these, 83.8% had positive tests for SARS-CoV-2, with the remainder serving as contemporaneous controls. The samples include nasopharyngeal swabs (57.9%), plasma (27.9%), and sera (12.5%). The associated clinical and demographic information available permits the evaluation of biological data in the context of patient demographics, clinical experience and management, vaccinations, and comorbidities. Conclusions: VA SHIELD is representative of US national diversity with a significant potential to impact national healthcare. VA SHIELD will support future projects designed to better understand SARS-CoV-2 and other emergent healthcare crises. To the extent possible, VA SHIELD will facilitate the discovery of diagnostics and therapeutics intended to diminish COVID-19 morbidity and mortality and to reduce the impact of new emerging threats to the health of US Veterans and populations worldwide.

Indexed as

biological specimen bankscommunicable diseasesCOVID-19 sequence analysisdata warehousinggovernment agencieshealth policypublic health surveillanceVeterans health

Identifiers

PMID36601554
PMCPMC9801224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.