Evidence map›Paper›PMID 36601514›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2022

Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats.

Sibi P Ittiyavirah, Kannan Ramalingam, Arathy Sathyan, R S Rajasree, Mohamed Saheer Kuruniyan, Syed Altafuddin Quadri, Muhammed Elayadeth-Meethal, Punnoth Poonkuzhi Naseef

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. A proprietary black cumin oil extract (Frontiers in nutrition · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sibi P IttiyavirahDepartment of Pharmaceutical Sciences, Centre for Professional and Advanced Sciences, Cheruvandoor, Kottayam 686631, India.
Kannan RamalingamDepartment of Pharmaceutical Sciences, Centre for Professional and Advanced Sciences, Cheruvandoor, Kottayam 686631, India.
Arathy SathyanDepartment of Pharmaceutical Sciences, Centre for Professional and Advanced Sciences, Cheruvandoor, Kottayam 686631, India.
R S RajasreeCollege of Pharmaceutical Sciences, Government Thirumala Devaswom Medical College, Alappuzha 688005, India.
Mohamed Saheer KuruniyanDepartment of Dental Technology, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia.
Syed Altafuddin QuadriDepartment of Dental Technology, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia.
Muhammed Elayadeth-MeethalDepartment of Animal Breeding and Genetics, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Wayanad 675621, India.
Punnoth Poonkuzhi NaseefDepartment of Pharmaceutics, Moulana College of Pharmacy, Perinthalmanna 679321, India.
King Khalid University · SAGovernment Medical College · INKerala Veterinary and Animal Sciences University · INMoulana Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation-mediated alterations in glutamate neurotransmission constitute the most important pathway in the pathophysiology of various brain disorders. The excessive signalling of glutamate results in excitotoxicity, neuronal degeneration, and neuronal cell death. In the present study, we investigated the relative efficacy of black cumin (

Indexed as

Black cuminExcitotoxicityIbotenic acidNeuroinflammationNigella sativaThymoquinone

Identifiers

PMID36601514
PMCPMC9805979
OpenAlexW4306767159

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.