Evidence map›Paper›PMID 36601439›Full record

ArticleAdvances in drug and alcohol research2022

Noncoding RNA therapeutics for substance use disorder.

Seyed Afshin Seyednejad, Gregory C Sartor

Open access · diamondAbstract read
In one paragraph

Article in Advances in drug and alcohol research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Cocaine remodels mFrontiers in cellular neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Seyed Afshin SeyednejadDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, United States.
Gregory C SartorDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, United States.
Institute of Cognitive and Brain Sciences · US

Funding

Neuronal subtype and circuit-specific epigenetic mechanisms in addictionR00DA040744 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI SARTOR, GREGORY CHARLES · 2018 to 2020
$745k
Nanodelivery therapeutic systems for substance use disorderU18DA052394 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI BAHAL, RAMAN · 2020 to 2020
$242k
NIDA NIH HHS R00 DA040744NIDA NIH HHS U18 DA052394
6 · The paper itself

Abstract

Although noncoding RNAs (ncRNAs) have been shown to regulate maladaptive neuroadaptations that drive compulsive drug use, ncRNA-targeting therapeutics for substance use disorder (SUD) have yet to be clinically tested. Recent advances in RNA-based drugs have improved many therapeutic issues related to immune response, specificity, and delivery, leading to multiple successful clinical trials for other diseases. As the need for safe and effective treatments for SUD continues to grow, novel nucleic acid-based therapeutics represent an appealing approach to target ncRNA mechanisms in SUD. Here, we review ncRNA processes implicated in SUD, discuss recent therapeutic approaches for targeting ncRNAs, and highlight potential opportunities and challenges of ncRNA-targeting therapeutics for SUD.

Indexed as

circRNAlncRNAmicroRNAnoncoding RNASMIRNAsubstance use disorder

Identifiers

PMID36601439
PMCPMC9808746
OpenAlexW4311939680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.