Evidence map›Paper›PMID 36601386›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Novel assay to measure chromosome instability identifies

Nikolay V Goncharov, Valeria A Kovalskaia, Alexander O Romanishin, Nikita A Shved, Andrei S Belousov, Vladlena S Tiasto, Valeriia S Gulaia, Vidushi S Neergheen, Nawraj Rummun, Mikhail Liskovykh and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Nikolay V GoncharovA.V. Zhirmunsky National Scientific Center of Marine Biology, Russian Academy of Sciences, Vladivostok, Russia.
Valeria A KovalskaiaResearch Centre for Medical Genetics, Moscow, Russia.
Alexander O RomanishinSchool of Life Sciences, Immanuel Kant Baltic Federal University, Kaliningrad, Russia.
Nikita A ShvedA.V. Zhirmunsky National Scientific Center of Marine Biology, Russian Academy of Sciences, Vladivostok, Russia.
Andrei S BelousovInstitute of Life Sciences and Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
Vladlena S TiastoInstitute of Life Sciences and Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
Valeriia S GulaiaInstitute of Life Sciences and Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
Vidushi S NeergheenBiopharmaceutical Unit, Centre for Biomedical and Biomaterials Research (CBBR), University of Mauritius, Réduit, Mauritius.
Nawraj RummunBiopharmaceutical Unit, Centre for Biomedical and Biomaterials Research (CBBR), University of Mauritius, Réduit, Mauritius.
Mikhail LiskovykhDevelopmental Therapeutics Branch, National Cancer Institute, NIH, Bethesda, MD, United States.
Vladimir LarionovDevelopmental Therapeutics Branch, National Cancer Institute, NIH, Bethesda, MD, United States.
Natalay KouprinaDevelopmental Therapeutics Branch, National Cancer Institute, NIH, Bethesda, MD, United States.
Vadim V KumeikoA.V. Zhirmunsky National Scientific Center of Marine Biology, Russian Academy of Sciences, Vladivostok, Russia.
Far Eastern Federal University · RUNational Cancer Institute · USUniversity of Mauritius · MUImmanuel Kant Baltic Federal University · RUResearch Centre for Medical Genetics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human artificial chromosomes (HACs) have provided a useful tool to study kinetochore structure and function, gene delivery, and gene expression. The HAC propagates and segregates properly in the cells. Recently, we have developed an experimental high-throughput imaging (HTI) HAC-based assay that allows the identification of genes whose depletion leads to chromosome instability (CIN). The HAC carries a

Indexed as

chromosome instabilityCINdouble-stranded breaksHAChuman artificial chromosomemicronucleinatural productsPunica granatum leave extract

Identifiers

PMID36601386
PMCPMC9806258
OpenAlexW4311951433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.