Evidence map›Paper›PMID 36601349›Full record

ArticleFrontiers in physiology2022

The des-Arg

Gabriel Moreira de M Mendes, Israel Júnior Borges Do Nascimento, Paulo Hs Marazzi-Diniz, Izabela B Da Silveira, Matheus F Itaborahy, Luiz E Viana, Filipe A Silva, Monique F Santana, Rebecca Aa Pinto, Bruna G Dutra and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. The Role of the Kinin System and the Effect of Des-ArginineInternational journal of molecular sciences · 2024
    Observational
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Gabriel Moreira de M MendesDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Israel Júnior Borges Do NascimentoEscola de Medicina e Hospital universitário, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Paulo Hs Marazzi-DinizDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Izabela B Da SilveiraDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Matheus F ItaborahyDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Luiz E VianaEscola de Medicina e Hospital universitário, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Filipe A SilvaDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Monique F SantanaUniversidade do Estado do Amazonas, Manaus, Brazil.
Rebecca Aa PintoUniversidade Federal do Amazonas, Manaus, Brazil.
Bruna G DutraUniversidade Federal do Amazonas, Manaus, Brazil.
Marcus Vinicius G LacerdaUniversidade do Estado do Amazonas, Manaus, Brazil.
Stanley A AraujoInstituto Mineiro de Nefropatologia, Belo Horizonte, Brazil.
David WanderleyInstituto Mineiro de Nefropatologia, Belo Horizonte, Brazil.
Paula Vt VidigalDepartamento de Anatomia Patológica e Medicina Legal, Escola de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Paulo Hc DinizDepartamento de Clínica Médica, Escola de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Thiago Verano-BragaDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Robson As SantosDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
M Fatima LeiteDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Universidade Federal de Minas Gerais · BRUniversidade do Estado do Amazonas · BRUniversidade Federal do Amazonas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients infected by the SARS-CoV-2 virus are commonly diagnosed with threatening liver conditions associated with drug-induced therapies and systemic viral action. RNA-Seq data from cells in bronchoalveolar lavage fluid from COVID-19 patients have pointed out dysregulation of kallikrein-kinin and renin-angiotensin systems as a possible mechanism that triggers multi-organ damage away from the leading site of virus infection. Therefore, we measured the plasma concentration of biologically active peptides from the kallikrein-kinin system, bradykinin and des-Arg

Indexed as

bradykininbradykinin 1 receptorcontact systemCOVID-19hepatic damagekinin-kallikrein systemrenin-angiotensin systemSARS-cov-2

Identifiers

PMID36601349
PMCPMC9806358
OpenAlexW4313396435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.