Evidence map›Paper›PMID 36601343›Full record

ArticleFrontiers in physiology2022

Cinacalcet inhibition of neuronal action potentials preferentially targets the fast inactivated state of voltage-gated sodium channels.

Jamie S Lindner, Salil R Rajayer, Briana J Martiszus, Stephen M Smith

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Exploring multiple drug actions of a CaNaunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jamie S LindnerSection of Pulmonary and Critical Care Medicine, VA Portland Health Care System, Portland, OR, United States.
Salil R RajayerSection of Pulmonary and Critical Care Medicine, VA Portland Health Care System, Portland, OR, United States.
Briana J MartiszusSection of Pulmonary and Critical Care Medicine, VA Portland Health Care System, Portland, OR, United States.
Stephen M SmithSection of Pulmonary and Critical Care Medicine, VA Portland Health Care System, Portland, OR, United States.
VA Portland Health Care System · US

Funding

Multidisciplinary Research Training in Pulmonary MedicineT32HL083808 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M., SLATORE, CHRISTOPHER G. · 2008 to 2025
$5.3M
Sodium channel control of neuronal excitabilityR01GM134110 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SMITH, STEPHEN M · 2020 to 2022
$652k
BLRD VA I01 BX002547NHLBI NIH HHS T32 HL083808NIGMS NIH HHS R01 GM134110
6 · The paper itself

Abstract

Voltage-gated sodium channel (VGSC) activation is essential for action potential generation in the brain. Allosteric calcium-sensing receptor (CaSR) agonist, cinacalcet, strongly and ubiquitously inhibits VGSC currents in neocortical neurons

Indexed as

action potentialcalcium-sensing receptorCaSRcinacalcetsodium channelvoltage-gated sodium channel

Identifiers

PMID36601343
PMCPMC9806421
OpenAlexW4313396455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.