ArticleFrontiers in endocrinology2022
The relationship between uric acid and total femur bone mineral density in hypertensive and non-hypertensive populations.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Clinical value of clinicopathological, ultrasonographic features and fibroblast activation protein in evaluating the radioiodine treatment efficacy in papillary thyroid carcinoma.Annals of nuclear medicine · 2026Article
- Nonlinear Association Between Serum Uric Acid and Femoral Neck Bone Mineral Density in Male Patients with Metabolic Dysfunction-Associated Fatty Liver Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.Frontiers in endocrinology · 2025Review
- Cardiometabolic index is associated with increased bone mineral density: a population-based cross-sectional study.Frontiers in public health · 2024Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to explore the association between uric acid (UA) and total femur bone mineral density (BMD) in hypertensive and non-hypertensive groups. Methods: We conducted a cross-sectional study of 13,108 participants in the NHANES database, including 4,679 hypertensive and 8,429 non-hypertensive subjects. A weighted multiple linear regression analysis was conducted to explore the association between UA and total femur BMD. Results: In the hypertensive group, the relationship between UA and total femur BMD was positive [β, 3.02 (95% CI, -0.44 to 6.48), p = 0.0962). In the non-hypertensive group, the association was significantly positive [β, 5.64 (95% CI, 2.06-9.22), p = 0.0038]. In gender-stratified analysis, UA was analyzed as a continuous variable and a categorical variable (quartile). The significantly positive association was present in both the hypertensive male group [β, 5.10 (95% CI, 0.98-9.21), p for trend = 0.0042] and non-hypertensive male group [β, 10.63 (95% CI, 6.32-14.94), p for trend = 0.0001]. A smooth curve fitting showed that in the hypertensive male group, the relationship between UA and total femur BMD was an inverted U-shaped curve. In the hypertensive female group, the relationship was basically negative. In the non-hypertensive population, the relationship between UA and total femur BMD was an inverted U curve in both men and women. Conclusion: In the hypertensive male group, the association between UA and total femur BMD was an inverted U-shaped curve. As to women, the relationship was basically negative. In the non-hypertensive group, the association between UA and total femur BMD was an inverted U-shaped curve in different genders.
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