Evidence map›Paper›PMID 36600997›Full record

ReviewJournal of tissue engineering

Biomaterials delivery strategies to repair spinal cord injury by modulating macrophage phenotypes.

Yuanliang Xia, Ruohan Yang, Hengyi Wang, Yulin Hou, Yuehong Li, Jianshu Zhu, Feng Xu, Changfeng Fu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yuanliang XiaDepartment of Spine Surgery, The First Hospital of Jilin University, Changchun, PR China.
Ruohan YangCancer Center, The First Hospital of Jilin University, Changchun, PR China.
Hengyi WangDepartment of Spine Surgery, The First Hospital of Jilin University, Changchun, PR China.
Yulin HouDepattment of Cardiology, Guangyuan Central Hospital, Guangyuan, PR China.
Yuehong LiDepartment of Spine Surgery, The First Hospital of Jilin University, Changchun, PR China.
Jianshu ZhuDepartment of Spine Surgery, The First Hospital of Jilin University, Changchun, PR China.
Feng XuDepartment of Spine Surgery, The First Hospital of Jilin University, Changchun, PR China.
Changfeng FuDepartment of Spine Surgery, The First Hospital of Jilin University, Changchun, PR China.ORCID https://orcid.org/0000-0001-5442-4413
Jilin University · CNTaiyuan Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) causes tremendous harm to a patient's physical, mental, and financial health. Moreover, recovery of SCI is affected by many factors, inflammation is one of the most important as it engulfs necrotic tissue and cells during the early stages of injury. However, excessive inflammation is not conducive to damage repair. Macrophages are classified into either blood-derived macrophages or resident microglia based on their origin, their effects on SCI being two-sided. Microglia first activate and recruit blood-derived macrophages at the site of injury-blood-borne macrophages being divided into pro-inflammatory M1 phenotypes and anti-inflammatory M2 phenotypes. Among them, M1 macrophages secrete inflammatory factors such as interleukin-β (IL-β), tumor necrosis factor-α (TNF-α), IL-6, and interferon-γ (IFN-γ) at the injury site, which aggravates SCIs. M2 macrophages secrete IL-4, IL-10, IL-13, and neurotrophic factors to inhibit the inflammatory response and inhibit neuronal apoptosis. Consequently, modulating phenotypic differentiation of macrophages appears to be a meaningful therapeutic target for the treatment of SCI. Biomaterials are widely used in regenerative medicine and tissue engineering due to their targeting and bio-histocompatibility. In this review, we describe the effects of biomaterials applied to modulate macrophage phenotypes on SCI recovery and provide an outlook.

Indexed as

BiomaterialsinflammationM1 macrophagesM2 macrophagesmicrogliaspinal cord injury

Identifiers

PMID36600997
PMCPMC9806413
OpenAlexW4313163902

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.