ArticleFrontiers in aging neuroscience2022
Baduanjin exercise modulates the hippocampal subregion structure in community-dwelling older adults with cognitive frailty.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Rethinking exercise dose for cognitive ageing: a systematic review and meta-analysis of physical dose and cognitive-motor demands.Frontiers in psychology · 2026Pooled it
- A Systematic Review of Frailty Interventions in Community-Based Low and Middle-Income Settings.International journal of public health · 2025Pooled it
- A meta-analysis of the influence of traditional Chinese exercises on cognitive function in the elderly.Frontiers in psychology · 2025Pooled it
- Effects of Baduanjin Exercise on lung function and 6 min walk in COPD patients: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- The neurobiological effects of mind-body exercise: a systematic review and meta-analysis of neuroimaging studies.Scientific reports · 2023Pooled it
- Selective Plasticity of Hippocampal Sub-Regions in the Amnestic Mild Cognitive Impairment After Acupuncture.Brain and behavior · 2025Trial
- Comparative effects of Baduanjin and square dance on working memory, executive function performance, mood, and fatigue in older women: a randomized controlled trial.Frontiers in psychology · 2026Article
- Four-Limb Coordinated Training and Neuroplasticity in Older Adults with Cognitive Frailty: Mechanisms and Clinical Evidence.Clinical interventions in aging · 2026Review
- Sleep-dependent alterations in anterior cingulate cortex excitation-inhibition balance link alterations in BOLD-CSF coupling to cognitive performance in obstructive sleep apnea.Frontiers in aging neuroscience · 2026Article
- Effects of combined Baduanjin and cognitive training on cognitive function in cognitively normal older adults.Frontiers in psychology · 2026Article
- Integrated Aerobic Exercise and Multisensory Environment Training for Age-related Cognitive Decline via Hippocampal-prefrontal Neural Circuit Modulation.Molecular neurobiology · 2025Article
- Efficacy of Baduanjin Versus Brisk Walking on Cognitive and Physical Functions in Schizophrenia: A Three-Arm Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Analysis of influencing factors of cognitive frailty in older adults community patients based on restricted cubic spline.Frontiers in public health · 2025Article
- The impact of exercise interventions on cognitive frailty: a scoping review of outcomes and biological mechanisms.Frontiers in public health · 2025Article
- Neuron collinearity differentiates human hippocampal subregions: a validated deep learning approach.Brain communications · 2024Article
- Hippocampal Subfield Volumes in Amateur Marathon Runners.Medicine and science in sports and exercise · 2023Article
- The modulation effects of the mind-body and physical exercises on the basolateral amygdala-temporal pole pathway on individuals with knee osteoarthritis.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Regular Baduanjin exercise intervention was proven to be beneficial in improving the cognitive ability and physical performance of older adults with different health conditions but was unclear to influence the structural plasticity of the hippocampus. This study aimed to explore the modulation of hippocampal subregions as a mechanism by which Baduanjin exercise improves cognitive frailty in older adults. Methods: A total of 102 community-dwelling older adults with cognitive frailty were recruited and randomly allocated to the Baduanjin exercise training group and usual physical activity control group. The participants in the Baduanjin exercise training group participated in a 24-week Baduanjin exercise intervention program with an exercise frequency of 60 min per day, 3 days per week. Cognitive ability and physical frailty were assessed, and MRI scans were performed on all participants at baseline and after 24 weeks of intervention. The structural MRI data were processed with MRIConvert (version 2.0 Rev. 235) and FreeSurfer (version 6.0.0) software. Data analyses were performed using the independent sample Results: After 24 weeks of intervention, a statistically significant increase was found for the Montreal Cognitive Assessment (MoCA) scores ( Conclusion: A 24-week Baduanjin exercise intervention effectively improved cognitive ability and reduced physical frailty in community-dwelling older adults with cognitive frailty, and the mechanism might be associated with modulating the structural plasticity of the hippocampal subregion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.